Understanding the role of microbiomes in severe pneumonia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the relationship between lung and intestinal microbiomes and host susceptibility in patients with severe pneumonia. By collecting clinical samples such as sputum, alveolar lavage fluid, feces, and whole blood from ICU patients, the study seeks to clarify how these microbiomes influence disease progression and prognosis. The research will be conducted across multiple centers from 2023 to 2025, addressing the limitations of previous studies that were often small and single-centered.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1\. New lung infection that meets one of the following definitions: the patient receives mechanical ventilation (invasive or non-invasive) due to acute respiratory failure, with a PEEP level of 5cm or above; Patients receiving high flow oxygen therapy with a FiO2 of 50% or more and a PaO2: FiO2 ratio below 300

Exclusion Criteria:

1. Expected length of stay in ICU is less than 1 day
2. Pregnant

Where it's running

• First Affiliated Hospital of Zhejiang University School of Medicine
  Hangzhou, Zhejiang, China Recruiting
• Shulan (Hangzhou) hospital
  Hangzhou, China Recruiting
• Tongde Hospital of Zhejiang Province
  Hangzhou, China Recruiting
• the First People's Hospital of Huzhou
  Huzhou, China Recruiting
• The First Hospital of Jiaxing
  Jiaxing, China Recruiting
• Lanxi Hospital of Traditional Chinese Medicine
  Lanxi, China Recruiting

Study contacts

• Principal investigator: Lingtong Huang, M.D. — First Affiliated Hospital of Zhejiang University
• Study coordinator: Lingtong Huang, M.D.
• Email: lingtonghuang@zju.edu.cn
• Phone: 0571-87236309

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.