Understanding the Role of Amyloidosis in Heart Failure
Official title: Prevalence of Cardiac Amyloidosis in Patients With Hospitalization for Acute Heart Failure in the French West Indies
Run by University Hospital Center of Martinique · NCT05501847 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is trying to see how amyloidosis affects heart failure in people from the West Indies, especially looking for gene mutations in those showing signs of heart problems.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 50 Years and up |
| Sex | All |
| Enrollment | 446 (estimated) |
| Sponsor | University Hospital Center of Martinique Academic / other |
| Locations | 2 sites (Pointe-à-Pitre and 1 other locations) |
| Trial ID | NCT05501847 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals showing functional signs of acute heart failure and confirmed by a cardiologist.
✕Probably not a fit
Patients without signs of heart failure or those under legal protection will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the relationship between cardiac amyloidosis and heart failure, particularly in the West Indian population. It focuses on patients exhibiting signs of acute heart failure and aims to identify the prevalence of transthyretin gene mutations that may contribute to this condition. The methodology includes clinical assessments and biomarker evaluations to confirm heart failure diagnosis. The study seeks to enhance understanding of this rare disease and its impact on heart function.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnosis and treatment strategies for heart failure related to amyloidosis, particularly in high-risk populations.
How similar studies have gone: While studies on heart failure are common, the specific focus on cardiac amyloidosis in the West Indian population is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Present functional or physical signs of acute heart failure (exertional dyspnea, orthopnea, paroxysmal nocturnal dyspnea, fatigue, jugular turgor, hepato-jugular reflux, edema of the lower limbs, galloping noise, crackles on pulmonary auscultation) * BNP \>100pg/mL or NT-proBNP \>300pg/mL * Diagnosis of heart failure confirmed by the cardiologist * Be affiliated to a social security plan or beneficiary * Be able to receive and understand information related to the research * Able to freely express his/her non-opposition or informed and written consent. Exclusion Criteria: * Person under legal protection (guardianship, curatorship, safeguard of justice), and person deprived of liberty.
Where it's running
-
CHU de Martinique
Fort-de-France, Martinique Recruiting -
Laurent LARIFLA
Pointe-à-Pitre, Guadeloupe Not yet recruiting
Study contacts
- Study coordinator: Jocelyne CRASPAG, MSc
- Email: jocelyne.craspag@chu-martinique.fr
- Phone: 0596592698
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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In adults in a long-term cardiac rehabilitation program, this study tests whether a personalized behavioural program with digital tools can reduce daily sitting time.
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NT-proBNP–guided heart failure screening for people 65+ in rural China
This study tests whether using NT-proBNP blood tests to guide heart failure screening in adults 65 and older in rural China can find unrecognized heart problems more effectively than symptom-based screening.
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Voice-based detection of heart failure deterioration using Noah Labs Vox
This study tests whether a voice-analysis app can flag worsening heart failure in adults by comparing its alerts to standard weight-based monitoring.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.