Understanding the Neurovegetative Patterns in Patients with Thoracic Aortic Aneurysms
Investigation of the Neurovegetative Pattern in the Adult Population With Thoracic Aortic Aneurysms (AAT)
This study is trying to see how blood pressure and breathing patterns change in people with thoracic aortic aneurysms to better understand their risk of complications.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 139 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | IRCCS Policlinico S. Donato Academic / other |
| Locations | 1 site (San Donato Milanese, Lombardia) |
| Trial ID | NCT05703893 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the vagal features in patients with both syndromic and non-syndromic thoracic aortic aneurysms (TAA). Participants will undergo non-invasive monitoring of blood pressure and respiratory patterns while in supine and standing positions to assess their neurovegetative responses. The goal is to identify functional conditions that may help stratify patients based on their risk of aortic complications. By analyzing these patterns, the study seeks to understand how environmental stressors affect blood pressure and the structural integrity of the aortic wall.
Who should consider this trial
Good fit: Ideal candidates include patients aged 18-65 with syndromic or non-syndromic thoracic aortic aneurysms who are either on pharmacological prophylaxis or newly diagnosed.
Not a fit: Patients with acute or chronic inflammatory diseases or those with significant thyroid dysfunction may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved risk stratification and management strategies for patients with thoracic aortic aneurysms.
How similar studies have performed: While there is existing literature on the sympathetic nervous system's role in blood pressure regulation, this specific approach to studying neurovegetative patterns in TAA is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged 18-65 years with syndromic and nonsyndromic TAA; * Signed informed consent; * Patients on regular pharmacological prophylaxis (with Losartan) or naïve patients with a first diagnosis Exclusion Criteria: * Acute and chronic inflammatory diseases such as: liver disease, chronic renal insufficiency (creatinine \> 1.5 mg/dl) and diseases affecting the thyroid system.
Where this trial is running
San Donato Milanese, Lombardia
- IRCCS Policlinico San Donato — San Donato Milanese, Lombardia, Italy (Recruiting)
Study contacts
- Study coordinator: Alessandro Pini, MD
- Email: alessandro.pini@grupposandonato.it
- Phone: +390252774705
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.