Understanding the natural history of olfactory neuroblastoma in patients
A Natural History Study of Children and Adults With Olfactory Neuroblastoma
This study is trying to learn more about olfactory neuroblastoma, a rare cancer in the nose, by gathering information on how it develops and affects patients to improve treatment options.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 525 (estimated) |
| Ages | 3 Years to 120 Years |
| Sex | All |
| Sponsor | National Institutes of Health Clinical Center (CC) NIH |
| Drugs / interventions | radiation |
| Locations | 1 site (Bethesda, Maryland) |
| Trial ID | NCT04755205 on ClinicalTrials.gov |
What this trial studies
This observational study aims to gather comprehensive data on olfactory neuroblastoma (ONB), a rare cancer affecting the nasal cavity. Researchers will evaluate the disease's progression, tumor characteristics, treatment responses, and management strategies through medical history reviews, blood samples, and surveys assessing patients' emotional and physical well-being. Participants will also undergo smell tests to assess their olfactory function. The study will collect clinical, epidemiologic, and biological data to enhance understanding and treatment of ONB.
Who should consider this trial
Good fit: Ideal candidates include individuals aged 3 years and older with histologically documented olfactory neuroblastoma.
Not a fit: Patients who are pregnant or unable to provide informed consent may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment strategies and supportive care for patients with olfactory neuroblastoma.
How similar studies have performed: While ONB is rare, similar observational studies in rare tumors have provided valuable insights, suggesting potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
* INCLUSION CRITERIA:. * Subjects with histologically documented olfactory neuroblastoma. * Age \>= 3 years old. * Ability of subject to understand and the willingness to sign a written consent document EXCLUSION CRITERIA: Pregnant women are excluded from this study because of more than minimal risk activities (imaging studies with contrast, biopsies) pertaining to enrollment.
Where this trial is running
Bethesda, Maryland
- National Institutes of Health Clinical Center — Bethesda, Maryland, United States (Recruiting)
Study contacts
- Principal investigator: Charalampos Floudas, M.D. — National Cancer Institute (NCI)
- Study coordinator: Marissa B Mallek, R.N.
- Email: marissa.mallek@nih.gov
- Phone: (240) 760-7498
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.