Understanding the natural history of hypereosinophilia and hypereosinophilic syndromes
Official title: Study of Clinical Profiles of Patients Followed for Chronic Hypereosinophilia and/or Hypereosinophilic Syndrome by the Creation of a National Cohort
Run by University Hospital, Lille · NCT04018118 · Data updated 2026-11-12
This study looks at how unexplained high eosinophil levels and related syndromes affect patients over time to better understand their symptoms and the factors that might influence their condition.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 600 (estimated) |
| Sponsor | University Hospital, Lille Academic / other |
| Locations | 1 site (Lille) |
| Status | Recruiting |
| Started | May 6, 2019 |
| Main results expected | May 6, 2029 |
| Study ends | May 2031 |
| Registry record updated | February 20, 2026 |
| Trial ID | NCT04018118 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals diagnosed with hypereosinophilia or hypereosinophilic syndrome, particularly those with eosinophil counts above 1500/mm3.
✕Probably not a fit
Patients with known HIV infection or those unable to provide informed consent may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to investigate the natural history of unexplained chronic hypereosinophilia (HE) and hypereosinophilic syndromes (HES). It will analyze the clinical and biological characteristics of patients, focusing on their evolutionary profiles and potential genetic and environmental factors. The study will categorize patients based on their disease progression, ranging from single flare-ups to chronic conditions requiring ongoing treatment. By collecting biological samples, the research seeks to uncover the underlying mechanisms of these syndromes and their impact on organ health.
Why it matters
Potential benefit: If successful, this study could lead to better understanding and management of hypereosinophilia and its associated syndromes, improving patient outcomes.
How similar studies have gone: While there is limited data on the natural history of HE and HES, similar studies on eosinophilic disorders have shown promise in understanding disease mechanisms.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Men or Women of any age : * With the diagnosis criteria of hyperosinophlia OR hypereosinophilic syndrome OR specific organ eosinophilic disease according to the consensus conference of the International Cooperative Working Group on Eosinophil Disorders (ICOG-EO) * With an AEC \> 1500/mm3 or organ damage related to the presence of eosinophils in the tissues or organs whatever the context (idiopathic, clonal or reactive, including drug-related, parasitic or allergic) * HES diagnosis since 2005/01/01 * Patients socially insured * Patient who agreed to participate to the study, its proceedings and duration. Exclusion Criteria: * Known HIV infection * Not socially insured * Person unable to receive a enlighten information * Person who refuse to sign the consent * Persons deprived of their liberty * Persons benefiting from a system of legal protection (tutelage / guardianship)
Where it's running
-
Hôpital Roger Salengro, CHU
Lille, France Recruiting
Study contacts
- Principal investigator: Guillaume Lefevre — University Hospital, Lille
- Study coordinator: Guillaume Lefevre, MD
- Email: Guillaume.lefevre@chru-lille.fr
- Phone: 03 20 44 55 72
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Long-term observation of familial hypereosinophilia and its effects
This study looks at a hereditary condition called familial hypereosinophilia to see how it affects people over time and to learn more about its causes and markers.
-
Using dupilumab to help patients with hypereosinophilic syndrome who still have symptoms
This study is testing if adding dupilumab to the treatment of adults with hypereosinophilic syndrome can help reduce their ongoing symptoms.
-
Understanding Eosinophils in Immune Conditions
This study is trying to understand how certain white blood cells called eosinophils behave in people with high eosinophil counts due to immune system diseases.
-
Machine learning to distinguish EGPA from HES
This project will test whether machine learning applied to clinical, lab, and instrument data can help tell EGPA apart from HES and predict how patients respond to treatment.
-
Registry of patients with eosinophilia affecting the respiratory system
This study is gathering information from patients with eosinophilic lung diseases to better understand how their blood eosinophil levels relate to their breathing problems and overall health.
-
European database and biobank for childhood interstitial lung diseases
This study is creating a database and biobank to collect information and samples from children with interstitial lung diseases across Europe to improve their treatment and understanding of these conditions.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.