Understanding the link between migraine and heart disease through blood analysis
A Proteomic Analysis for Understanding the Link Between Migraine and Cardiovascular Disease
This study looks at how migraines might be connected to heart disease by testing blood samples from people with and without migraines to see if there are any important differences.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 90 (estimated) |
| Ages | 25 Years to 60 Years |
| Sex | All |
| Sponsor | Centro Cardiologico Monzino Academic / other |
| Locations | 1 site (Milano, Milan) |
| Trial ID | NCT06372509 on ClinicalTrials.gov |
What this trial studies
This multicenter, prospective observational study aims to analyze the relationship between migraine and cardiovascular disease by collecting data from 90 patients aged 25 to 60 years, both with and without migraine. Participants will be classified into two groups: those with migraine with aura and those who are migraine-free. The study will involve a comprehensive clinical assessment and targeted proteomic evaluation of blood samples to identify proteins associated with cardiovascular risk factors and diseases. The goal is to uncover potential correlations that could enhance understanding of the interplay between migraine and cardiovascular health.
Who should consider this trial
Good fit: Ideal candidates are adults aged 25 to 60 years who are hospitalized for non-coronary artery diseases and have either migraine with aura or are migraine-free.
Not a fit: Patients under 25 or over 60 years old, or those with acute myocardial infarction or severe heart conditions, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights that improve the management of patients with migraines and cardiovascular diseases.
How similar studies have performed: While the relationship between migraine and cardiovascular disease has been explored, this specific proteomic approach is relatively novel and may provide new insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \>25 years and \> 60 years * Signed patient informed consent form (ICF) * Non-coronary disease Exclusion Criteria: * Age \< 25 years and \> 60 years * Acute myocardial infarction (MI) * Chronic kidney disease: glomerular filtration rate (GFR) \< 30 ml/min * Severe mitral or aortic valvular disease * Acute heart failure * Reduced left ventricular (LV) function (Ejection Fraction \< 35%) * Atrial Fibrillation
Where this trial is running
Milano, Milan
- Centro Cardiologico Monzino — Milano, Milan, Italy (Recruiting)
Study contacts
- Study coordinator: Daniela Trabattoni, MD
- Email: daniela.trabattoni@cardiologicomonzino.it
- Phone: 0258002780
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.