Understanding the link between body mass index and treatment response in idiopathic intracranial hypertension

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the relationship between body mass index (BMI) and treatment outcomes in patients with idiopathic intracranial hypertension (IIH). It seeks to determine the BMI thresholds associated with the onset of IIH and the necessary BMI reduction for effective treatment. The study will assess how patients respond to treatments like Acetazolamide and cerebrospinal fluid diversion systems, particularly focusing on those who struggle to lose weight. By identifying specific BMI goals for individual patients, the study hopes to enhance treatment efficacy and patient awareness.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 18 years and older at the time of enrollment. There is no upper age limit to ensure inclusivity across age ranges.
* A confirmed diagnosis of Idiopathic Intracranial Hypertension, established according to the Dandy criteria.
* The diagnostic process must exclude other potential causes of increased intracranial pressure as detailed in the 'Diagnosis' section, ensuring an accurate identification of idiopathic cases.

Exclusion Criteria:

* A diagnosis other than IIH, specifically: tension-type headache, Chiari I malformation, or any other headache disorder unrelated to IIH.
* The presence of secondary causes of increased intracranial pressure (e.g., structural brain abnormalities, venous sinus thrombosis, or medication-induced factors).

Where it's running

• Consorcio Hospital General Universitario de Valencia
  Valencia, Valencia, Spain Recruiting

Study contacts

• Study coordinator: Vicente Vanaclocha, Professor
• Email: vivava@uv.es
• Phone: + 34 963 13 18 00

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Tirzepatide for Idiopathic Intracranial Hypertension

  This trial tests whether tirzepatide can help people with idiopathic intracranial hypertension by comparing it to placebo over 12 months.

  Recruiting Phase 4 Duke University · Durham, North Carolina · NCT07191873

• Advanced imaging techniques for understanding idiopathic intracranial hypertension

  This study is testing advanced imaging techniques on patients with stubborn idiopathic intracranial hypertension to see how stenting affects their brain fluid flow and overall condition.

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• Transverse sinus stenting for people with long-term intracranial hypertension on acetazolamide

  This trial will test whether adding a stent in the narrowed transverse sinus helps adults with idiopathic intracranial hypertension who have been on acetazolamide for over a year but still have symptoms.

  Recruiting University Hospital, Montpellier · Montpellier and 2 other locations · NCT06945848

• Transverse sinus stenting for newly diagnosed idiopathic intracranial hypertension

  This will test whether adding transverse venous sinus stenting to standard medical care helps adults with newly diagnosed idiopathic intracranial hypertension improve vision, headaches, or tinnitus.

  Recruiting University Hospital, Montpellier · Montpellier and 2 other locations · NCT06919744

• Comparing CSF shunts and dural venous sinus stents for IIH

  This will test whether a CSF shunt or a dural venous sinus stent better reduces pressure and preserves vision in adults with IIH who have severe papilloedema and are at risk of vision loss.

  Recruiting at 13 sites University of Birmingham · Birmingham and 14 other locations · NCT07440277

• Evaluating eye images to assess brain pressure

  This study is testing a new way to see if eye images can help tell if someone has high pressure in their brain, using a non-invasive method that could be safer than current techniques.

  Recruiting King's College Hospital NHS Trust · London, London · NCT06855342

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.