Understanding the impact of brain swelling in stroke patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the role of perihaematomal oedema (PHO) in patients with spontaneous intracerebral hemorrhage (ICH), a severe type of stroke. It aims to clarify the mechanisms and clinical significance of PHO by utilizing brain MRI and analyzing biological biomarkers. Patients will be enrolled within 12 hours of stroke onset to assess the natural history and potential therapeutic targets related to PHO. The findings could provide insights into improving treatment strategies for ICH.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* With a spontaneous ICH, i.e. non traumatic
* Admitted within 12 hours of stroke onset. For wake-up strokes, time of last seen well will be considered as stroke onset
* Patient insured under the French social security
* Consent form signed

Exclusion Criteria:

* Pure intraventricular haemorrhages
* "secondary" ICH: ICH resulting from intracranial vascular malformation, intracranial venous thrombosis, head trauma or tumour; haemorrhagic transformation within an infarct
* Pre-admission modified Rankin score of 4 or 5
* Life expectancy of less than 1 year related to comorbidities (end stage cancer, end stage organ failure)
* Pregnancy or breastfeeding or Women of childbearing age without effective contraception (a pregnancy test will be done)
* Adults who are deprived of their liberty by judicial or administrative decision
* Referral from other hospitals
* Contra-indication to MRI : claustrophobia, ocular metallic foreign bodies (accidental or other) or in a risk area (nervous or vascular system);irremovable implanted medical device (pacemaker, neurostimulator, cochlear implants and others);metallic heart valve (mainly old heart valves) or vascular clips previously implanted on cranial aneurysms; gadolinium allergy
* No consent form

Where it's running

• CHU de Lille
  Lille, France Recruiting

Study contacts

• Principal investigator: Charlotte Cordonnier, MD,PhD — University Hospital, Lille
• Study coordinator: Charlotte Cordonnier, MD,PhD
• Email: charlotte.cordonnier@chu-lille.fr
• Phone: 0320445962

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.