Understanding the genetic structure of ASXL1-mutated myelofibrosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to explore the clonal architecture of patients with ASXL1 mutations in primary and secondary myelofibrosis to better understand its prognostic implications. It will involve a multicenter cohort of 50 patients, with blood samples collected within 18 months of diagnosis. Over a follow-up period of four years, data on patient survival and potential leukemic transformation will be gathered to refine the prognostic impact of ASXL1 mutations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults (age ≥18 years),
* Affiliated to the national social security system,
* ASXL1 mutated primary or secondary myelofibrosis,
* Signed the consent to participate in the study,
* Included, or consenting to be included, in the national clinical-biological database of France Intergroupe Syndrome Myéloprolifératifs (FIM).

Exclusion Criteria:

* Patient with another active hematological disease or cancer at the time of diagnosis,
* Person subject to legal protection scheme or incapable of giving consent.

Where it's running

• CHU Angers
  Angers, France Recruiting
• CHU Henri MONDOR
  Créteil, France Recruiting
• Institut Paoli Calmettes
  Marseille, France Recruiting
• Hôpital Bicêtre
  Paris, France Recruiting
• CHU de Bordeaux
  Pessac, France Recruiting
• CHU Lyon
  Pierre-Bénite, France Recruiting

Study contacts

• Study coordinator: Margaux Wiber, PharmD.
• Email: margaux.wiber@chu-angers.fr
• Phone: 0033241355553

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.