Understanding the genetic causes of moles
Genetic Basis of Melanocytic Nevi
This study is trying to find out the genetic changes that cause moles by looking at DNA from skin samples and blood to better understand these common skin growths.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of California, Davis Academic / other |
| Locations | 1 site (Sacramento, California) |
| Trial ID | NCT03054584 on ClinicalTrials.gov |
What this trial studies
This study aims to investigate the genetic mutations associated with melanocytic nevi, commonly known as moles. Researchers will collect DNA from skin biopsy specimens of nevi and corresponding blood samples to perform whole genome, whole exome, or targeted sequencing. The goal is to identify somatic mutations in the nevi by comparing them to normal tissue DNA. This observational approach will help clarify the genetic basis of these benign skin lesions.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older who have melanocytic nevi.
Not a fit: Patients under 18 years of age or those without melanocytic nevi will not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of melanocytic nevi, potentially improving patient outcomes.
How similar studies have performed: While this study focuses on genetic analysis of nevi, similar genetic studies have shown promise in understanding other skin conditions, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria: * Male or female subjects that are 18 years or older * Subjects with melanocytic nevi\\ Exclusion criteria: * Patients less than 18 years of age * Patients without melanocytic nevi * Patients with a bleeding disorder or are taking anticoagulation medication
Where this trial is running
Sacramento, California
- University of California-Davis, Department of Dermatology — Sacramento, California, United States (Recruiting)
Study contacts
- Study coordinator: Maija Kiuru, MD
- Email: mkiuru@ucdavis.edu
- Phone: 916-734-0591
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.