Understanding the genetic causes of language development disorders in children

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on children diagnosed with Developmental Language Disorder (DLD) to investigate the genetic underpinnings of this condition. By utilizing high-throughput sequencing, the research aims to distinguish sub-groups of children with language difficulties that are not associated with other known disorders. Eligible participants will undergo a blood draw for genetic analysis, and the study seeks to improve the understanding of DLD by examining a more homogeneous cohort. The goal is to clarify the clinical heterogeneity of language disorders and enhance future research and clinical practices.

Why it matters

Who can join: the full rules

Patients

Inclusion Criteria:

* Eligible families included at least one child over five years old with a formal diagnosis of severe and isolated DLD according to Phase 2 CATALISE criteria . Patients have undergone age-appropriate speech, language and reading evaluations by a speech-language physician and cognitive evaluations by a neuropsychologist, as well as evaluation by a pediatric neurologist to identify co-occurring developmental disorders (ADHD, ASD…) and a medical geneticist for known genetic disorders and genetic testing recommendations. All children included received appropriate speech therapy for at least one year, with a progress report indicating the persistence of language difficulties.

Exclusion Criteria:

* Cognitive impairment with non-verbal intellectual quotient (IQ) below 2 SD assessed with the Wechsler Preschool and Primary Scale of Intelligence (WPPSI), or the Wechsler Intelligence Scale for Children (WISC-IV or V) according to the age-appropriateness, ASD, moderate to severe hearing loss, orofacial structural abnormalities, known neurological or genetic disorders at the initial assessment. None of the patients met the diagnostic criteria for CAS according to the ASHA (American Speech-Language-Hearing Association, 2007. Childhood apraxia of speech www.asha.org/policy).

Where it's running

• Hopital Sud Francilien
  Corbeil-Essonnes, France Recruiting
• Raymond Poincaré- Garches
  Garches, France Recruiting
• Hopital Necker
  Paris, France Recruiting

Study contacts

• Study coordinator: Vincent Cantagrel, PhD
• Email: vincent.cantagrel@inserm.fr
• Phone: 33 142754237

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.