Understanding the effects of occupational exposure to PAH mixtures
Biological Signatures (Proteomics, Metabolomics and Genotoxicity) Associated With Occupational Exposure to PAH Mixtures and Relation With Exposure Biomarkers: Support for the Derivation of Biological Limit Values
This study is trying to see how being exposed to certain chemicals at work affects people's health and if it can help find early signs of health problems.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | Male |
| Sponsor | University Hospital, Grenoble Academic / other |
| Locations | 1 site (Grenoble) |
| Trial ID | NCT05679544 on ClinicalTrials.gov |
What this trial studies
This research project investigates the biological effects of occupational exposure to complex mixtures of Polycyclic Aromatic Hydrocarbons (PAHs). It aims to identify early biomarkers of exposure and health effects related to PAH exposure, focusing on metabolic disturbances, protein deficiencies, and genotoxicity. The study will characterize the molecular and metabolic impacts of PAH exposure and link these effects to biological levels of various PAH metabolites. By improving our understanding of these pathways, the research seeks to enhance biomonitoring efforts and inform health risk assessments.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals aged 18 and older who have been occupationally exposed to PAHs for more than three months.
Not a fit: Patients with obesity, existing cancers, or metabolic diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to the identification of new biomarkers that improve health monitoring for individuals exposed to PAHs.
How similar studies have performed: While there is ongoing research into PAH exposure, this study aims to explore novel biomarkers and mechanisms, making it a potentially unique contribution to the field.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Subjects ages 18 years or more * Subjects occupationally exposed to PAHs since more than 3 months * Having signed the informed consent * recruited by the occupational health service Exclusion Criteria: * Obesity (BMI\>30) * Subjects suffering cancers or metabolic diseases (diabetes, dyslipidemia, amino-acid diseases, renal or hepatic impairment) at the onset of the study. * Subjects taking medications related to the above diseases at the onset of the study.
Where this trial is running
Grenoble
- CHU Grenoble Alpes — Grenoble, France (Recruiting)
Study contacts
- Principal investigator: Renaud PERSOONS — University Hospital, Grenoble
- Study coordinator: Renaud PERSOONS, PhD, Pharm D
- Email: RPersoons@chu-grenoble.fr
- Phone: 00 33 4 76 76 51 78
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.