Understanding the causes of primary immune deficiencies
Pathophysiologie Angeborener Immundefekte
This study looks at the causes of primary immune deficiencies to see how they affect the body's ability to fight infections and inflammation, with hopes of creating better treatments for those affected.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Sex | All |
| Sponsor | University of Zurich Academic / other |
| Locations | 1 site (Zurich) |
| Trial ID | NCT03422614 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the pathophysiology of primary immunodeficiencies (PID), which are conditions that lead to increased susceptibility to infections and inflammatory responses. Researchers will collect and analyze various biological samples, including stool, urine, blood, tissue biopsies, and bone marrow, to assess anti-microbial activity and inflammatory responses. The findings may pave the way for the development of targeted treatments tailored to the specific underlying causes of different PIDs.
Who should consider this trial
Good fit: Ideal candidates for this study include individuals with a clinical diagnosis of an inborn error of immunity.
Not a fit: Patients with secondary immunodeficiencies or those who do not have an inborn error of immunity may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more effective and targeted treatments for patients with primary immune deficiencies.
How similar studies have performed: While the study addresses a complex area of immunology, similar studies have shown promise in understanding and treating immune deficiencies, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Clinical diagnosis of an inborn error of immunity (primary immunodeficiency, PID) * Clinically healthy (non-age matched) volunteer Exclusion Criteria: * exclusion of an inborn error of immunity * secondary immunodeficiency * refusal to enter the study
Where this trial is running
Zurich
- University Children's Hospital Zurich — Zurich, Switzerland (Recruiting)
Study contacts
- Principal investigator: Janine Reichenbach, Prof. Dr. — University Children's Hospital, Zurich
- Study coordinator: Janine Reichenbach, Prof. Dr.
- Email: janine.reichenbach@kispi.uzh.ch
- Phone: +41442667311
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.