Clinical trial Recruiting at 1 site Observational Ages 18 to 99

Understanding the biology of Pulmonary Recurrent Respiratory Papillomatosis

Official title: The Natural History and Biological Study of Pulmonary Recurrent Respiratory Papillomatosis (pRRP)

Run by Massachusetts General Hospital · NCT06412172 · Data updated 2026-11-12

This study is collecting tissue samples from patients with Pulmonary Recurrent Respiratory Papillomatosis to better understand the disease and find new treatments.

More Recurrent Respiratory Papillomatosis trials

Quick facts

Study typeObservational
Ages18 Years to 99 Years
SexAll
Enrollment100 (estimated)
SponsorMassachusetts General Hospital
Academic / other
Locations1 site (New Haven, Connecticut)
StatusRecruiting
StartedApril 15, 2024
Main results expectedApril 14, 2026
Study endsApril 15, 2030
Registry record updatedAugust 12, 2025
Trial IDNCT06412172 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are individuals with a history of HPV-associated Recurrent Respiratory Papillomatosis and pulmonary lesions.

Probably not a fit

Patients without a diagnosis of HPV-associated Recurrent Respiratory Papillomatosis or those without pulmonary lesions may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to collect and analyze tissue samples from patients diagnosed with Pulmonary Recurrent Respiratory Papillomatosis (pRRP), a rare disease caused by HPV types 6 and 11. By establishing a tissue repository, the study will facilitate genetic and immunologic research to uncover the underlying biology of this condition and the immune responses involved. The collected samples will include both fresh and archived tissues, which will be de-identified to protect patient privacy. The goal is to develop novel therapies based on the findings from these analyses.

Why it matters

Potential benefit: If successful, this study could lead to the development of new and effective treatments for patients suffering from Pulmonary Recurrent Respiratory Papillomatosis.

How similar studies have gone: While RRP is an understudied condition, similar approaches in other rare diseases have shown promise in understanding disease biology and developing targeted therapies.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* History of HPV-associated Recurrent Respiratory Papillomatosis
* Has pulmonary lesions

Exclusion Criteria:

* None

Where it's running

  • Yale School of Medicine
    New Haven, Connecticut, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.