Understanding the biology of Pulmonary Recurrent Respiratory Papillomatosis
Official title: The Natural History and Biological Study of Pulmonary Recurrent Respiratory Papillomatosis (pRRP)
Run by Massachusetts General Hospital · NCT06412172 · Data updated 2026-11-12
This study is collecting tissue samples from patients with Pulmonary Recurrent Respiratory Papillomatosis to better understand the disease and find new treatments.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 99 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Massachusetts General Hospital Academic / other |
| Locations | 1 site (New Haven, Connecticut) |
| Status | Recruiting |
| Started | April 15, 2024 |
| Main results expected | April 14, 2026 |
| Study ends | April 15, 2030 |
| Registry record updated | August 12, 2025 |
| Trial ID | NCT06412172 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals with a history of HPV-associated Recurrent Respiratory Papillomatosis and pulmonary lesions.
✕Probably not a fit
Patients without a diagnosis of HPV-associated Recurrent Respiratory Papillomatosis or those without pulmonary lesions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to collect and analyze tissue samples from patients diagnosed with Pulmonary Recurrent Respiratory Papillomatosis (pRRP), a rare disease caused by HPV types 6 and 11. By establishing a tissue repository, the study will facilitate genetic and immunologic research to uncover the underlying biology of this condition and the immune responses involved. The collected samples will include both fresh and archived tissues, which will be de-identified to protect patient privacy. The goal is to develop novel therapies based on the findings from these analyses.
Why it matters
Potential benefit: If successful, this study could lead to the development of new and effective treatments for patients suffering from Pulmonary Recurrent Respiratory Papillomatosis.
How similar studies have gone: While RRP is an understudied condition, similar approaches in other rare diseases have shown promise in understanding disease biology and developing targeted therapies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * History of HPV-associated Recurrent Respiratory Papillomatosis * Has pulmonary lesions Exclusion Criteria: * None
Where it's running
-
Yale School of Medicine
New Haven, Connecticut, United States Recruiting
Study contacts
- Principal investigator: Sara Pai — Yale University
- Study coordinator: Sara Pai, MD, PhD
- Email: RRPBiorepository@yale.edu
- Phone: 203-785-5820
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.