Understanding the biology of Pulmonary Recurrent Respiratory Papillomatosis
The Natural History and Biological Study of Pulmonary Recurrent Respiratory Papillomatosis (pRRP)
This study is collecting tissue samples from patients with Pulmonary Recurrent Respiratory Papillomatosis to better understand the disease and find new treatments.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years to 99 Years |
| Sex | All |
| Sponsor | Massachusetts General Hospital Academic / other |
| Locations | 1 site (New Haven, Connecticut) |
| Trial ID | NCT06412172 on ClinicalTrials.gov |
What this trial studies
This observational study aims to collect and analyze tissue samples from patients diagnosed with Pulmonary Recurrent Respiratory Papillomatosis (pRRP), a rare disease caused by HPV types 6 and 11. By establishing a tissue repository, the study will facilitate genetic and immunologic research to uncover the underlying biology of this condition and the immune responses involved. The collected samples will include both fresh and archived tissues, which will be de-identified to protect patient privacy. The goal is to develop novel therapies based on the findings from these analyses.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals with a history of HPV-associated Recurrent Respiratory Papillomatosis and pulmonary lesions.
Not a fit: Patients without a diagnosis of HPV-associated Recurrent Respiratory Papillomatosis or those without pulmonary lesions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to the development of new and effective treatments for patients suffering from Pulmonary Recurrent Respiratory Papillomatosis.
How similar studies have performed: While RRP is an understudied condition, similar approaches in other rare diseases have shown promise in understanding disease biology and developing targeted therapies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * History of HPV-associated Recurrent Respiratory Papillomatosis * Has pulmonary lesions Exclusion Criteria: * None
Where this trial is running
New Haven, Connecticut
- Yale School of Medicine — New Haven, Connecticut, United States (Recruiting)
Study contacts
- Principal investigator: Sara Pai — Yale University
- Study coordinator: Sara Pai, MD, PhD
- Email: RRPBiorepository@yale.edu
- Phone: 203-785-5820
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.