Understanding the biology and prognosis of cerebral arteriovenous malformations
Official title: Biology of Cerebral Arteriovenous Malformations : Study of the Link Between Blood Biomarkers and the Haemorrhagic Prognosis of Cerebral Arteriovenous Malformations
Run by Fondation Ophtalmologique Adolphe de Rothschild · NCT03676868 · Data updated 2026-11-12
This study is trying to learn more about cerebral arteriovenous malformations (AVMs) and how they can cause strokes, focusing on how certain blood vessels and immune cells work, to help improve care for adults with AVMs.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 0 Years and up |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | Fondation Ophtalmologique Adolphe de Rothschild Research network |
| Locations | 1 site (Paris) |
| Status | Recruiting |
| Started | November 20, 2018 |
| Main results expected | November 19, 2028 |
| Study ends | November 19, 2028 |
| Registry record updated | June 25, 2025 |
| Trial ID | NCT03676868 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults over 18 years old diagnosed with a cerebral AVM requiring intervention or clinical monitoring.
✕Probably not a fit
Patients who are pregnant, breastfeeding, or under legal protection measures may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to investigate the biology of cerebral arteriovenous malformations (AVMs) and their associated prognosis. It focuses on understanding the mechanisms behind hemorrhagic strokes caused by AVMs, particularly the role of peri-nidal micro-vessels and the involvement of immune cells and platelets in maintaining microvascular integrity. Patients over 18 years old with cerebral AVMs will be monitored, and their consent will be obtained for participation. The study seeks to gather data that could enhance the understanding of AVMs and improve patient outcomes.
Why it matters
Potential benefit: If successful, this study could lead to better management and treatment strategies for patients with cerebral arteriovenous malformations.
How similar studies have gone: While there have been studies on cerebral AVMs, this specific observational approach focusing on the biology and prognosis is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient over 18 years old * Patient with a cerebral AVM for which an intervention (endovascular treatment or surgery) or only clinical monitoring * Express consent to participate in the study And * children * Free informed and express consent of both holders of the minor patient's parental authority, or, by way of derogation and only if the other holder of parental authority cannot give his or her consent within a time limit compatible with the methodological requirements specific to the conduct of the research with regard to its purposes, of one of the two holders of parental authority Exclusion Criteria: * Patient benefiting from a legal protection measure * Pregnant or breast feeding woman
Where it's running
-
Fondation Ophtalmologique Rotschild
Paris, France Recruiting
Study contacts
- Study coordinator: Amélie Yavchitz
- Email: ayavchitz@for.paris
- Phone: 01 48 63 64 54
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.