Understanding Sympathetic Nerve Activity in COPD Patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational project aims to investigate the overactivity of the sympathetic nerve activity (SNA) axis in patients with chronic obstructive pulmonary disease (COPD). Utilizing advanced technology and a multimodal approach, the study will assess the extent and nature of increased SNA, as well as the underlying mechanisms contributing to this phenomenon. Factors such as obstructive sleep apnea, inspiratory muscle dysfunction, pulmonary hypertension, and systemic inflammation will be evaluated to provide insights into their roles in COPD. The research is conducted at the RWTH Aachen University Hospital's respiratory and autonomic nervous system physiology laboratory.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18
* Ability and willingness to give informed consent to participate in the study

Exclusion Criteria:

* Atrial fibrillation
* Active pacing of the heart by a cardiac pacemaker (i.e. no intrinsic heart rate)
* Clinically pre-established cardiovascular disease (e.g. arterial hypertension or systolic heart failure)
* In-patient stay in the hospital within the last 4 weeks prior to the study examination date

Where it's running

• RWTH Aachen University
  Aachen, Germany Recruiting

Study contacts

• Principal investigator: Jens Spiesshoefer, MD — RWTH Aachen University
• Study coordinator: Michael Dreher, Professor
• Email: mdreher@ukaachen.de
• Phone: +492418088763

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• AERO-007: a inhaled LABA+LAMA combination for COPD through a nebulizer

  This study tests whether a nebulized LABA+LAMA combination can improve lung function in adults with COPD.

  Recruiting Phase 2 AeroRx Therapeutics Inc. · London and 1 other locations · NCT07896252

• Cognitive load and inhaler technique in COPD

  This study tests whether adding a short memory task while using an inhaler makes COPD patients more likely to misuse their inhaler.

  Recruiting Spitalul Clinic de Boli Infecțioase și Pneumoftiziologie Dr. Victor Babeș Timișoara · Timișoara, Timiș County · NCT07786220

• Balance training after pulmonary rehab for COPD to help steadiness and reduce falls

  A COPD-focused balance training program called Sport4Steadiness is being tested to see if people with COPD will accept it and if the study processes work well.

  Recruiting at 3 sites Teesside University · Middlesbrough and 2 other locations · NCT07750821

• Continuous vs High-Intensity Interval Exercise in COPD

  This study tests whether continuous versus high-intensity interval exercise affects cerebral oxygenation in people with COPD.

  Recruiting George Papanicolaou Hospital · Thessaloniki, Exohi · NCT07707271

• Biomarker clues for COPD, IPF, and lung cancer

  This study tests whether inflammation, immune, genetic, and epigenetic markers at enrollment can explain how COPD, IPF, or lung cancer present and behave, in order to see if these markers can predict outcomes over a year.

  Recruiting Fondazione Don Carlo Gnocchi ETS · Milan, Milan · NCT07707245

• HRS-9821 Inhalation Suspension for COPD: Safety and Dose Finding in Adults

  This study tests whether HRS-9821 inhalation can be safely taken and help people with moderate to severe COPD, and aims to find a reasonable dose.

  Recruiting Phase 2 Guangdong Hengrui Pharmaceutical Co., Ltd · Shanghai, Shanghai Municipality · NCT07640451

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.