Understanding respiratory viral infections in pediatric transplant recipients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the relationship between pre-transplant respiratory viral load and the occurrence of respiratory viral infections (RVI) in pediatric patients who have undergone hematopoietic cell or solid organ transplants. Participants will provide nasal swabs and blood samples at enrollment and if they develop an RVI within one year post-transplant. The study also seeks to develop predictive classifiers based on immunological profiles collected before and after the transplant to identify those at risk for acute respiratory viral infections. The goal is to improve patient outcomes by enhancing pre-transplant screening processes.

Why it matters

Who can join: the full rules

Recipient Inclusion Criteria

* Less than 18 years at the time of anticipated transplant
* Participant meets one of the following criteria:

  1. scheduled to receive allogeneic hematopoietic cell transplant within 14 days of enrollment or
  2. Scheduled to or received solid organ transplant within 7 days before or after enrollment
* Participant is receiving care at the time of enrollment at one of the study participating institutions.
* Parent/guardian willing and able to provide informed consent, and if appropriate, child willing and able to provide informed assent.

Donor Inclusion Criteria

* Donor for HCT recipient enrolled on the VIPER study.
* Willing and able to provide informed consent.

Exclusion Criteria:

Recipient Exclusion Criteria

None

Donor Exclusion Criteria

* Is not an HCT donor for a participant enrolled on the VIPER study.
* Not available to provide pre-transplant research blood sample.

Where it's running

• University of Alabama at Birmingham's (UAB)
  Birmingham, Alabama, United States Recruiting
• Arkansas Children's Hospital
  Little Rock, Arkansas, United States Recruiting
• Children's National Medical
  Washington D.C., District of Columbia, United States Recruiting
• University if Miami
  Miami, Florida, United States Recruiting
• Emory and Children's Healthcare of Atlanta
  Atlanta, Georgia, United States Recruiting
• University of Chicago Medicine Comer Children's Hospital
  Chicago, Illinois, United States Recruiting

Study contacts

• Principal investigator: Gabriela Maron, MD — St. Jude Children's Research Hospital
• Study coordinator: Gabriela Maron, MD
• Email: referralinfo@stjude.org
• Phone: 866-278-5833

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• JKN2301 dry suspension versus oseltamivir for treating flu in children 2 to under 12.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.