Clinical trial Recruiting at 2 sites Observational Ages 18 and up

Understanding resistance in multiple myeloma

Official title: MYeloma Resistance And Clonal Evolution

Run by Nantes University Hospital · NCT03807128 · Data updated 2026-11-12

This study is trying to understand why some people with multiple myeloma don’t respond to treatment by collecting data and blood samples from patients at specialized cancer centers in Northwestern France.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment1400 (estimated)
SponsorNantes University Hospital
Academic / other
Locations2 sites (La Roche-sur-Yon and 1 other locations)
StatusRecruiting
StartedFebruary 11, 2019
Main results expectedFebruary 11, 2034
Study endsFebruary 11, 2049
Registry record updatedJuly 14, 2025
Trial IDNCT03807128 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults over 18 years old diagnosed with multiple myeloma.

Probably not a fit

Patients under 18 years old or those under guardianship will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on patients diagnosed with multiple myeloma (MM) at specialized oncology centers in Northwestern France. It aims to gather comprehensive data on the biological mechanisms of therapeutic resistance, as well as predictors of this resistance, through continuous follow-up and collection of socio-economic, medical, and quality of life information. Participants will also provide blood samples for analysis to identify potential biomarkers and improve diagnostics. The study includes all patients over 18 years old diagnosed with MM, ensuring a diverse cohort for better insights.

Why it matters

Potential benefit: If successful, this study could lead to improved understanding and management of multiple myeloma, potentially enhancing patient outcomes.

How similar studies have gone: While studies on multiple myeloma have been conducted, this specific approach focusing on resistance mechanisms and quality of life is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patient consulting due to the discovery or recurrence of MM according to international diagnostic criteria (IMWG 2014)
* Patient having consented to participate in the study and his/her biocollection
* Patient affiliated to or benefiting from a social security scheme or similar

Exclusion Criteria:

* Minors
* Major under guardianship or curatorship
* Protected persons.
* Pregnant or breast-feeding women
* Persons benefiting from the AME

Where it's running

  • La Roche sur Yon Hospital Departmental
    La Roche-sur-Yon, France
    Recruiting
  • Nantes University Hospital
    Nantes, France
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.