Understanding resistance in multiple myeloma
Official title: MYeloma Resistance And Clonal Evolution
Run by Nantes University Hospital · NCT03807128 · Data updated 2026-11-12
This study is trying to understand why some people with multiple myeloma don’t respond to treatment by collecting data and blood samples from patients at specialized cancer centers in Northwestern France.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 1400 (estimated) |
| Sponsor | Nantes University Hospital Academic / other |
| Locations | 2 sites (La Roche-sur-Yon and 1 other locations) |
| Status | Recruiting |
| Started | February 11, 2019 |
| Main results expected | February 11, 2034 |
| Study ends | February 11, 2049 |
| Registry record updated | July 14, 2025 |
| Trial ID | NCT03807128 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults over 18 years old diagnosed with multiple myeloma.
✕Probably not a fit
Patients under 18 years old or those under guardianship will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study focuses on patients diagnosed with multiple myeloma (MM) at specialized oncology centers in Northwestern France. It aims to gather comprehensive data on the biological mechanisms of therapeutic resistance, as well as predictors of this resistance, through continuous follow-up and collection of socio-economic, medical, and quality of life information. Participants will also provide blood samples for analysis to identify potential biomarkers and improve diagnostics. The study includes all patients over 18 years old diagnosed with MM, ensuring a diverse cohort for better insights.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of multiple myeloma, potentially enhancing patient outcomes.
How similar studies have gone: While studies on multiple myeloma have been conducted, this specific approach focusing on resistance mechanisms and quality of life is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient consulting due to the discovery or recurrence of MM according to international diagnostic criteria (IMWG 2014) * Patient having consented to participate in the study and his/her biocollection * Patient affiliated to or benefiting from a social security scheme or similar Exclusion Criteria: * Minors * Major under guardianship or curatorship * Protected persons. * Pregnant or breast-feeding women * Persons benefiting from the AME
Where it's running
-
La Roche sur Yon Hospital Departmental
La Roche-sur-Yon, France Recruiting -
Nantes University Hospital
Nantes, France Recruiting
Study contacts
- Principal investigator: Cyrille TOUZEAU, PU — Nantes University Hospital
- Study coordinator: Cyrille TOUZEAU, PU
- Email: cyrille.touzeau@chu-nantes.fr
- Phone: 02 40 08 32 71
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.