Understanding recovery mechanisms after stroke
A Novel Approach to the Development of New Treatment Strategies to Enhance True Recovery After Stroke, Based on Laboratory Movement Analysis and Clinical Aspects of Gait Function and Walking
Danderyd Hospital · NCT05359367
This study looks at how people recover their walking ability after a stroke to find better ways to help them improve.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 30 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Danderyd Hospital (other) |
| Locations | 1 site (Danderyd, Stockholm) |
| Trial ID | NCT05359367 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the pathophysiological mechanisms behind gait disturbances during the early recovery phase following a hemiparetic stroke. It will involve repeated clinical assessments and examinations of muscle activation patterns, walking kinematics, and neurological function at various intervals post-stroke. The study will include thirty patients admitted to inpatient rehabilitation, with a focus on identifying potential targets for new treatment strategies based on the findings. The goal is to enhance recovery outcomes for stroke patients.
Who should consider this trial
Good fit: Ideal candidates are patients who have suffered a hemiparetic stroke and have specific mobility impairments requiring rehabilitation.
Not a fit: Patients with severe contractures or other conditions that prevent participation in intensive gait training may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved rehabilitation strategies for stroke patients, enhancing their recovery of function.
How similar studies have performed: While this approach is observational, similar studies have shown promise in understanding recovery mechanisms post-stroke, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participants with hemiplegia, dependence in ambulation (1- 4 according to the Functional Ambulation Categories (FAC)), * \>= 50 points on the Trunk Control Test. * Impaired dorsiflexion manifested as impaired voluntarily dorsiflexion and inability to hold the ankle in a dorsiflexed position while sitting, and for ambulatory participants, impaired dorsiflexion during swing phase and initial contact during visual inspection of gait. * Recommended for an ancle foot orthosis (AFO) by an experienced physiotherapist. Able to understand study information and provide informed consent. Exclusion Criteria: * Contracture that severely restricts gait movements in a lower limb joint, * cardiovascular or other somatic condition incompatible with intensive gait training, * notifiable infectious disease, contagious infections (e.g. MRSA or ESBL) * Inability to participate in the rehabilitation intervention due to behavioral or psychiatric disorder * when magnetic resonance imaging will be performed, additional exclusion criteria are current or history of epilepsy, metal implants in the brain/skull cochlear implants, any implanted neurostimulator, cardiac pacemaker or cardiac implants of metal and infusion device.
Where this trial is running
Danderyd, Stockholm
- Department of Rehabilitation Medicine, Danderyd Hospital — Danderyd, Stockholm, Sweden (RECRUITING)
Study contacts
- Principal investigator: Susanne M Palmcrantz, PhD — Dep of Clinical Sciences, Karolinska Institutet
- Study coordinator: Susanne Palmcrantz, PhD
- Email: susanne.palmcrantz@ki.se
- Phone: +46 (0)709567653
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Stroke, Inpatients, Recovery of Function, Observational Study