Understanding recovery and compensation after stroke
Locomotor Recovery and Compensation Post-stroke (LRC)
This study is testing how different types of stepping exercises can help people recover after a stroke, both soon after and later on, to see if they can improve their movement and overall recovery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 150 (estimated) |
| Ages | 18 Years to 85 Years |
| Sex | All |
| Sponsor | Indiana University Academic / other |
| Locations | 1 site (Indianapolis, Indiana) |
| Trial ID | NCT05081713 on ClinicalTrials.gov |
What this trial studies
This research aims to characterize the timeline of neurological and locomotor recovery following a stroke, as well as the development of compensatory strategies during the sub-acute and chronic phases. The study will explore how specific interventions, particularly high-intensity training focused on stepping, can influence recovery outcomes in both early and late stages post-stroke. By examining the relationship between initial motor deficits and recovery patterns, the study seeks to establish new predictive rules for functional recovery in stroke patients. The findings could challenge existing beliefs about the role of therapy dosage in long-term recovery.
Who should consider this trial
Good fit: Ideal candidates include individuals who are early post-stroke, experiencing their first stroke, with unilateral hemiparesis, and currently receiving inpatient rehabilitation.
Not a fit: Patients with uncontrolled cardiovascular, metabolic, or respiratory diseases that limit exercise participation may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved rehabilitation strategies that enhance locomotor recovery for stroke patients.
How similar studies have performed: Other studies have shown success with high-intensity training approaches in rehabilitation, suggesting potential for meaningful advancements in stroke recovery.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria: * individuals early post-stroke (\<15-30 days) * first ever stroke * unilateral hemiparesis * currently receiving inpatient rehabilitation * ability to follow 1-step commands * provision of informed consent * medical clearance from the rehabilitation physician to participate. \\ Exclusion criteria: * uncontrolled cardiovascular, metabolic or respiratory disease that limits exercise participation (e.g., congestive heart failure, resting blood pressure \> 200/110 mmHg, uncontrolled diabetes, end-stage renal disease) * absolute criteria for termination of exercise testing during initial and repeated ECG testing during graded exercise testing using ACSM guidelines . * other orthopedic or neurological disorder that limited walking prior to stroke
Where this trial is running
Indianapolis, Indiana
- Rehabilitation Hospital of Indiana — Indianapolis, Indiana, United States (Recruiting)
Study contacts
- Principal investigator: Thomas G Hornby — Indiana University
- Study coordinator: Thomas G Hornby
- Email: tghornby@Iu.edu
- Phone: 3173292353
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.