Understanding recovery and compensation after stroke
Official title: Locomotor Recovery and Compensation Post-stroke (LRC)
Run by Indiana University · NCT05081713 · Data updated 2026-11-12
This study is testing how different types of stepping exercises can help people recover after a stroke, both soon after and later on, to see if they can improve their movement and overall recovery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 85 Years |
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | Indiana University Academic / other |
| Locations | 1 site (Indianapolis, Indiana) |
| Status | Recruiting |
| Started | September 1, 2021 |
| Main results expected | February 28, 2028 |
| Study ends | February 28, 2028 |
| Registry record updated | March 5, 2026 |
| Trial ID | NCT05081713 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals who are early post-stroke, experiencing their first stroke, with unilateral hemiparesis, and currently receiving inpatient rehabilitation.
✕Probably not a fit
Patients with uncontrolled cardiovascular, metabolic, or respiratory diseases that limit exercise participation may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This research aims to characterize the timeline of neurological and locomotor recovery following a stroke, as well as the development of compensatory strategies during the sub-acute and chronic phases. The study will explore how specific interventions, particularly high-intensity training focused on stepping, can influence recovery outcomes in both early and late stages post-stroke. By examining the relationship between initial motor deficits and recovery patterns, the study seeks to establish new predictive rules for functional recovery in stroke patients. The findings could challenge existing beliefs about the role of therapy dosage in long-term recovery.
Why it matters
Potential benefit: If successful, this study could lead to improved rehabilitation strategies that enhance locomotor recovery for stroke patients.
How similar studies have gone: Other studies have shown success with high-intensity training approaches in rehabilitation, suggesting potential for meaningful advancements in stroke recovery.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion criteria: * individuals early post-stroke (\<15-30 days) * first ever stroke * unilateral hemiparesis * currently receiving inpatient rehabilitation * ability to follow 1-step commands * provision of informed consent * medical clearance from the rehabilitation physician to participate. \\ Exclusion criteria: * uncontrolled cardiovascular, metabolic or respiratory disease that limits exercise participation (e.g., congestive heart failure, resting blood pressure \> 200/110 mmHg, uncontrolled diabetes, end-stage renal disease) * absolute criteria for termination of exercise testing during initial and repeated ECG testing during graded exercise testing using ACSM guidelines . * other orthopedic or neurological disorder that limited walking prior to stroke
Where it's running
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Rehabilitation Hospital of Indiana
Indianapolis, Indiana, United States Recruiting
Study contacts
- Principal investigator: Thomas G Hornby — Indiana University
- Study coordinator: Thomas G Hornby
- Email: tghornby@Iu.edu
- Phone: 3173292353
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Deep phenotyping to explore recovery in young adults after stroke
This project will test whether a detailed health and sample-collection approach (deep phenotyping) is practical and acceptable for people aged 18–55 who have had a stroke.
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Stem cell therapy for chronic stroke recovery
This study is testing whether using a patient's own stem cells can help people with long-term stroke recovery feel better and improve their daily functioning.
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AI-based tools to help diagnose, treat and predict stroke outcomes across multiple hospitals
This study tests AI-powered tools on real-world stroke patients to see if they can improve pre-hospital triage, diagnosis, and outcome prediction while data stay securely within each hospital.
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Web-based therapy using action observation and mirror therapy for arm weakness after stroke
This trial tests whether a mobile telerehabilitation app delivering action observation therapy (AOT) alone or combined AOT with mirror therapy (AOT-MT) can improve upper limb function in people with subacute stroke.
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Remote Ischaemic Conditioning for Fatigue After Stroke 2
Aat least 12 weeks after stroke, adults with post-stroke fatigue will try a simple hand-arm cuff treatment at home to see if it helps reduce fatigue.
-
Dual-task balance training plus computer-based cognitive training after stroke
In adults who recently had a stroke, the study tests whether adding computerized cognitive exercises to balance training improves balance and other recovery outcomes.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.