Understanding rare eye diseases

Structural and Functional Characterization of Rare Ocular Diseases

Observational Barcelona Macula Foundation · NCT05258032

This study is trying to learn more about rare eye diseases that affect vision, like Retinitis Pigmentosa and Stargardt Disease, by looking at how they develop over time in people who have them.

Quick facts

Study typeObservational
Enrollment50 (estimated)
Ages18 Years and up
SexAll
SponsorBarcelona Macula Foundation Academic / other
Locations1 site (Barcelona)
Trial IDNCT05258032 on ClinicalTrials.gov

What this trial studies

This observational study focuses on rare ocular diseases that affect the posterior segment of the eye, particularly inherited retinal degenerations. It aims to characterize the structural and functional aspects of conditions such as Retinitis Pigmentosa, Stargardt Disease 1, Best Disease, Pattern Dystrophy of Macula, and Choroideremia. By examining the natural history of these diseases, the study seeks to gather valuable data that could inform future treatment approaches. Participants will undergo various ophthalmic exams to assess their conditions.

Who should consider this trial

Good fit: Ideal candidates are individuals aged 18 and older diagnosed with a rare ocular disease affecting the posterior segment.

Not a fit: Patients with other concurrent posterior segment disorders or those currently involved in other ocular clinical trials may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could enhance understanding of rare ocular diseases and pave the way for future therapeutic interventions.

How similar studies have performed: While the study focuses on rare diseases, similar observational studies have previously contributed to advancements in understanding and treating ocular conditions.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Male or female 18 years or older with a diagnosis of a ROD affecting the posterior segment
* Patients able to undergo all required ophthalmic exams
* Patients able and willing to sign an informed consent

Exclusion Criteria:

* Patients with other concomitant posterior segment disorders
* Patients taking drugs known to affect the retina and/or optic nerve
* Patients that underwent an intraocular surgery (aside from phacoemulsification with intraocular lens implantation), corneal or glaucoma surgery
* Patients who have participated in the past 12 months or that are currently participating in clinical trials for an ocular disease

Where this trial is running

Barcelona

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Retinitis PigmentosaStargardt Disease 1Best DiseasePattern Dystrophy of MaculaChoroideremiaRetinitis pigmentosaStargardt's disease 1Best disease
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.