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Clinical trial Recruiting at 2 sites Observational Ages 18 and up Women only

Understanding pregnancy outcomes in Indigenous American women in the Midwest

Official title: Midwest Birth Outcomes and American Indian Pregnancy: Associations With Historical Trauma and Psychosocial Stress

Run by Sanford Health · NCT06008561 · Data updated 2026-11-12

This study looks at how stress and past trauma affect pregnancy outcomes for Indigenous American women in the Midwest to help improve their health and reduce issues like preterm births and infant mortality.

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Quick facts

Study typeObservational
Ages18 Years and up
SexWomen only
Enrollment80 (estimated)
SponsorSanford Health
Academic / other
Locations2 sites (Fargo, North Dakota and 1 other locations)
StatusRecruiting
StartedOctober 31, 2023
Main results expectedDecember 20, 2027
Study endsDecember 20, 2027
Registry record updatedNovember 5, 2026
Trial IDNCT06008561 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are Indigenous American women who are at least 18 years old and less than 26 weeks pregnant with a healthy single baby.

Probably not a fit

Patients who have undergone assistive reproductive technology or have a history of cardiac and endocrine disease may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on the pregnancy experiences of Indigenous American women in the Midwest, particularly examining how historical trauma and stress impact adverse pregnancy outcomes. By collecting data on the women's experiences with trauma, stress, and physiological responses, the study aims to uncover the biological mechanisms that contribute to high rates of infant mortality and preterm births in this population. The findings could lead to targeted interventions to address these health disparities and improve perinatal health outcomes for Indigenous American women.

Why it matters

Potential benefit: If successful, this study could provide insights that lead to improved interventions and support for Indigenous American women during pregnancy, ultimately reducing adverse outcomes.

How similar studies have gone: While there is limited research specifically addressing this population, studies focusing on psychosocial stressors and pregnancy outcomes have shown promise in other contexts, indicating potential for success in this novel approach.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* At least 18 years old
* Less than 26 weeks
* Healthy single baby pregnancy
* Indigenous American

Exclusion Criteria:

* Assistive reproductive technology (in-vitro fertilization)
* Have a history of cardiac and endocrine disease

Where it's running

  • Sanford Health
    Fargo, North Dakota, United States     Recruiting
  • Sanford Health
    Sioux Falls, South Dakota, United States     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.