Understanding platelet behavior in aortic stenosis
Platelet Adhesion in the Pathobiology of Aortic Stenosis
This study is trying to see how platelets behave in people with aortic stenosis to find new ways to slow down the disease for those with mild to moderate cases.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 65 (estimated) |
| Ages | 25 Years and up |
| Sex | All |
| Sponsor | University of Virginia Academic / other |
| Locations | 1 site (Charlottesville, Virginia) |
| Trial ID | NCT05550896 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the role of platelet adhesion in the pathobiology of aortic stenosis, a condition affecting a significant portion of the elderly population. It aims to identify potential pharmacologic interventions that could slow disease progression in patients with mild to moderate calcific aortic stenosis. Participants will undergo echocardiography to assess their condition and compare findings between those with aortic stenosis and age-matched controls without the disease. The study seeks to enhance understanding of the disease's progression and potential treatment avenues.
Who should consider this trial
Good fit: Ideal candidates include individuals over 25 years old with mild to moderate calcific aortic stenosis as determined by recent echocardiography.
Not a fit: Patients with severe aortic stenosis or those without any form of aortic stenosis will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to new strategies for slowing the progression of aortic stenosis, potentially reducing the need for surgical interventions.
How similar studies have performed: While there have been attempts to address aortic stenosis progression, this specific focus on platelet adhesion is relatively novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria For AS group * Age \>25 years of age * Mild or moderate calcific, non-congenital aortic stenosis by echocardiography within the prior 3 months defined as: * aortic valve area 1.0 cm2 - 1.9 cm2 and either * peak velocity of \>2.5 m/s and \<4.0 m/s with normal or mildly reduced stroke volume index (\>25 ml/m2), or * VTI ratio (LVOT:AoV) of \<0.5 and \>0.25 with abnormal stroke volume (\<35 ml/m2 or \>60 ml/m2). * Age and sex-matched control subjects undergoing echocardiography with no aortic stenosis, and no more than mild severity disease of other valves. Inclusion criteria for Control Group Exclusion Criteria: -
Where this trial is running
Charlottesville, Virginia
- University of Virginia — Charlottesville, Virginia, United States (Recruiting)
Study contacts
- Study coordinator: Jonathan Lindner, MD
- Email: jlindner@virginia.edu
- Phone: 434 297-9442
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.