Understanding pancreatic fat and cyst features in patients
Official title: Determination of Pancreatic Steatosis Prevalence and Correlation With High-risk Cyst Features in Patients With Pre-malignant Pancreatic Cystic Neoplasms Using Magnetic Resonance Imaging and Endoscopic Ultrasound
Run by Chinese University of Hong Kong · NCT05334836 · Data updated 2026-11-12
This study is trying to see if measuring fat in the pancreas and liver can help find early signs of dangerous pancreatic cysts in patients who might be at risk for pancreatic cancer.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 236 (estimated) |
| Sponsor | Chinese University of Hong Kong Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Shatin, New Territories) |
| Status | Recruiting |
| Started | April 6, 2022 |
| Main results expected | April 30, 2027 |
| Study ends | April 30, 2027 |
| Registry record updated | October 27, 2026 |
| Trial ID | NCT05334836 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18 or older with at least one pancreatic cystic lesion or healthy subjects.
✕Probably not a fit
Patients with known pancreatic cancer, prior pancreatic resection, or significant alcohol consumption may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to determine the prevalence of pancreatic steatosis and its correlation with high-risk features of pancreatic cysts. It involves screening patients with pancreatic cystic lesions presumed to be intraductal papillary mucinous neoplasms (IPMN) or mucinous cystic neoplasms (MCN) using MRI for quantifying pancreatic and liver fat. The goal is to enhance early detection and surveillance of pre-malignant lesions to improve outcomes for patients at risk of pancreatic cancer.
Why it matters
Potential benefit: If successful, this study could lead to earlier detection and better management of pancreatic cancer, potentially improving survival rates.
How similar studies have gone: Other studies have shown promise in using imaging techniques for early detection of pancreatic lesions, indicating that this approach may be beneficial.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age 18 or older 2. Patients with at least 1 pancreatic cystic lesion presumed to be IPMN or MCN based on CT, MRI or EUS features, with a cyst size ≥ 5mm; or healthy subjects. 3. Patients who are able to provide written informed consent to participate in the study and comply with the study procedures. Exclusion Criteria: 1. Unable to provide written informed consent 2. Patients with metallic implants or other contraindications to MRI 3. Patients with contraindications for endoscopy due to comorbidities 4. Patients with known pancreatic cancer or prior pancreatic resection 5. Patients with significant alcohol consumption, defined as alcohol intake of over 20 g daily (140 g weekly) for men and 10 g daily (70 g weekly) for women
Where it's running
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Prince of Wales Hospital, The Chinese University of Hong Kong
Shatin, New Territories, Hong Kong Recruiting
Study contacts
- Principal investigator: Raymond S Tang, MD — Chinese University of Hong Kong
- Study coordinator: Felix Sia
- Email: felixsia@cuhk.edu.hk
- Phone: 26370428
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Examining the link between pancreatic steatosis and pancreatic cysts and cancer
This study is trying to see if having fat in the pancreas is more common in people with pancreatic cysts that could turn into cancer and those with pancreatic cancer.
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Blood and cyst fluid analysis from patients undergoing pancreatic cyst surgery
Researchers will collect blood and cyst fluid from adults having pancreatic cysts surgically removed to test for DNA, RNA, and proteins.
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In-depth characterisation of biliary strictures and hepato‑pancreato‑biliary focal lesions to support new diagnostic technologies
This project will collect detailed imaging and tissue data from adults with suspected bile duct, liver, pancreatic, or gallbladder lesions to help develop and test better diagnostic tools.
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Patient-reported outcomes after pancreatic surgery
This project will see how pancreatic surgery affects quality of life and whether adults who have pancreatic resection feel satisfied with their decision over time.
-
Ultrasound elastography score to measure pancreatic fat
We will test an ultrasound-based score that measures pancreatic fat to see if it links to insulin-producing cell function and diabetes risk in adults with or at risk for metabolic syndrome.
-
Laparoscopic versus robot-assisted left-sided pancreas removal for benign and premalignant lesions
This trial will randomize adults needing elective left-sided pancreas removal for benign or premalignant lesions to laparoscopic or robot-assisted minimally invasive surgery to see if one approach leads to faster recovery and fewer complications.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.