Understanding pain processing in fibromyalgia and rheumatoid arthritis
Pain Processing in Inflammatory and Non-Inflammatory Chronic Pain Syndromes
This study is trying to understand how people with fibromyalgia and rheumatoid arthritis experience pain in similar ways to help improve treatment options.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | University of Florida Academic / other |
| Locations | 1 site (Gainesville, Florida) |
| Trial ID | NCT05277025 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the mechanisms of pain processing in patients with fibromyalgia and rheumatoid arthritis. It focuses on how these conditions may share overlapping pain mechanisms, leading to both nociceptive and nociplastic pain experiences. By analyzing patients who meet specific criteria for these chronic pain syndromes, the study seeks to deepen the understanding of pain mechanisms and their implications for treatment. The study will include participants aged 18-70 who fulfill established diagnostic criteria for fibromyalgia and rheumatoid arthritis.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18-70 diagnosed with fibromyalgia or rheumatoid arthritis.
Not a fit: Patients with conditions such as diabetes, cancer, or advanced organ disease may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved pain management strategies for patients suffering from fibromyalgia and rheumatoid arthritis.
How similar studies have performed: Other studies have explored pain mechanisms in chronic pain syndromes, indicating potential for meaningful insights, though this specific approach may be novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Ages 18-70 * Fulfills the 1990 and 2011 American College of Rheumatology Criteria for FM * Fulfills the 2010 ACR-EULAR classification criteria for RA * Healthy volunteers: No significant pain/fatigue/depression/anxiety. Exclusion Criteria: * Diabetes * Cancer * Advanced liver, kidney or cardiovascular disease * Neuropathic pain
Where this trial is running
Gainesville, Florida
- University of Florida — Gainesville, Florida, United States (Recruiting)
Study contacts
- Principal investigator: Roland Staud, M.D. — University of Florida
- Study coordinator: Roland Staud, M.D.
- Email: staudr@ufl.edu
- Phone: 352-294-8200
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.