Understanding oropharyngeal carcinoma and its connection to HPV
Official title: Multidimensional and Multimodal Profiling of Oropharyngeal Carcinoma
Run by Stanford University · NCT05880797 · Data updated 2026-11-12
This study is trying to learn more about oropharyngeal cancer and its link to HPV by collecting blood samples from patients to see how the disease changes over time.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 1000 (estimated) |
| Sponsor | Stanford University Academic / other |
| Locations | 1 site (Palo Alto, California) |
| Status | Recruiting |
| Started | July 7, 2023 |
| Main results expected | August 2027 |
| Study ends | August 2027 |
| Registry record updated | September 15, 2026 |
| Trial ID | NCT05880797 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients diagnosed with oropharyngeal carcinoma or those with HPV-associated cancer of unknown primary origin.
✕Probably not a fit
Patients who are not willing to sign consent will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to enhance the understanding of the natural history of oropharyngeal carcinoma (OPC), particularly in relation to human papilloma virus (HPV). Researchers will collect blood samples from patients diagnosed with OPC before treatment and at six follow-up time points to analyze changes over time. The study focuses on both HPV-associated and non-associated cases to provide a comprehensive profile of the disease. By gathering this data, the study seeks to uncover insights that could inform future treatment strategies.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of oropharyngeal carcinoma, potentially enhancing patient outcomes.
How similar studies have gone: While this study employs a novel approach to profiling OPC, similar studies have shown promise in understanding cancer biology and patient outcomes.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients diagnosed with oropharyngeal carcinoma or patients with cancer of the unknown primary that is HPV associated, or possibly deemed to be originating from the oropharynx. Exclusion Criteria: * Not willing to sign consent
Where it's running
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Stanford University
Palo Alto, California, United States Recruiting
Study contacts
- Principal investigator: Chris Holsinger, MD — Stanford University
- Study coordinator: Nikita Bedi
- Email: nbedi@stanford.edu
- Phone: (650) 723-5957
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This study tests whether giving an HPV self-sampling kit in the emergency department can help under-screened women get screened for cervical cancer and find those with HPV to guide follow-up care.
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Transoral and neck ultrasound to find suspected oropharyngeal (throat) cancers
This study will test whether adding transoral and neck ultrasound to the usual diagnostic tests helps doctors find oropharyngeal (throat) cancers more accurately in adults referred for suspicion of oropharyngeal cancer.
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Selective dose reduction of neck radiation in HPV-associated oropharyngeal cancer
This trial tests whether lowering radiation doses to certain neck lymph nodes or gross disease areas is safe and can reduce side effects for adults with HPV-related oropharyngeal cancer.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.