Understanding Non-IgE-mediated Food Allergies in Children

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on non-IgE-mediated gastrointestinal food allergies in children, which include conditions like food protein-induced enterocolitis syndrome and food protein-induced enteropathy. The study aims to evaluate the clinical features, natural history, and pathophysiology of these food allergies in the pediatric population. By gathering data on these conditions, the research seeks to improve understanding and management of non-IgE-mediated food allergies, which are often poorly defined and can lead to diagnostic delays. The study will involve children aged 0-14 years who have a suggestive history of food allergies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* subjects aged between 0-14 years
* suggestive history of food allergy

Exclusion Criteria:

* age \>14 years-
* chronic systemic diseases,
* malignancy,
* immunodeficiency,
* infectious diseases,
* autoimmune diseases,
* inflammatory bowel diseases,
* celiac disease,
* metabolic and genetic diseases,
* cystic fibrosis,
* chronic pulmonary diseases,
* gastrointestinal, respiratory, urinary tract and/or cardiovascular malformations,
* neurologic and/or neuropsychiatric disorders,
* gastrointestinal tract eosinophilic disorders,
* use of immunomodulating drugs, steroids, pre-pro-synbiotics, antibiotics in the previous 4 months

Where it's running

• University of Naples Federico II
  Naples, Italy Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Finding the best way to diagnose food protein-induced enterocolitis syndrome

  This study is testing a new way to diagnose food protein-induced enterocolitis syndrome (FPIES) in people aged 1-60 by giving them small amounts of food to see how they react.

  Recruiting at 2 sites NYU Langone Health · New York, New York and 1 other locations · NCT06683521

• Study of Children With Acute Food Protein Induced Enterocolitis Syndrome

  This study is trying to gather information about children with a rare food allergy called FPIES to better understand their symptoms and how the condition changes over time.

  Recruiting at 12 sites Fondation Lenval · Angers and 18 other locations · NCT05528900

• Remibrutinib for IgE-mediated peanut, milk, and egg allergy

  This study tests whether remibrutinib can help people with peanut, milk, or egg allergies by comparing it to placebo over 52 weeks.

  Recruiting at 22 sites Phase 3 Novartis · Birmingham, Alabama and 21 other locations · NCT07768371

• Steroids for allergic reactions to food in children

  This study will test whether giving steroids in addition to adrenaline and antihistamines helps children who have allergic reactions during supervised food challenges.

  Recruiting at 2 sites Phase 4 University Children's Hospital, Zurich · Basel, Basel and 1 other locations · NCT07341776

• Tolerance of a hydrolyzed rice-protein baby formula in children with cow's milk allergy.

  This will test whether a new hydrolyzed rice-protein formula causes allergic reactions in infants and young children (1–36 months) with IgE-mediated cow's milk allergy.

  Recruiting Health and Happiness Research Limited · Naples · NCT07197814

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.