Understanding neutropenia in children with Duffy-null phenotype
Retrospective Analysis of a Cohort of Duffy-null Associated Neutrophil Count (DANC) Pediatric Patients
This study looks at how common and severe low white blood cell counts are in children with a specific genetic trait and whether these low counts are linked to more infections.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Ages | N/A to 16 Years |
| Sex | All |
| Sponsor | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico Academic / other |
| Locations | 1 site (Milano) |
| Trial ID | NCT06547931 on ClinicalTrials.gov |
What this trial studies
This observational study aims to characterize neutropenia associated with the Duffy-null phenotype in pediatric patients. It focuses on defining the frequency of immune neutropenia and evaluating the severity of neutropenia in this specific cohort. Additionally, the study will assess the potential relationship between varying degrees of neutropenia and the occurrence of infections. Data will be collected and analyzed to provide insights into this condition.
Who should consider this trial
Good fit: Ideal candidates for this study are pediatric patients who exhibit the Duffy-null phenotype.
Not a fit: Patients without the Duffy-null phenotype will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding and management of neutropenia in children with the Duffy-null phenotype.
How similar studies have performed: There is limited existing data on this specific condition, making this approach novel and untested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * presence of Duffy-null phenotype Exclusion Criteria: * absence of Duffy-null phenotype
Where this trial is running
Milano
- Fondazione IRCCS Ca' Granda Ospedale Maggioe Policlinico — Milano, Italy (Recruiting)
Study contacts
- Study coordinator: Alessandra Cattaneo
- Email: alessandra.cattaneo@policlinico.mi.it
- Phone: 0255034252
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.