Understanding muscle force control in COPD patients

Knee Extensors Force Control in People With Chronic Obstructive Pulmonary Disease

This study looks at how Chronic Obstructive Pulmonary Disease (COPD) affects the ability of patients to control their muscle strength compared to healthy people.

Quick facts

• Study type: Observational
• Enrollment: 36 (estimated)
• Ages: 40 Years and up
• Sex: All
• Sponsor: Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer (other)
• Locations: 1 site (Toulon, VAR)
• Trial ID: NCT06871670 on ClinicalTrials.gov

What this trial studies

This observational study investigates the deficits in force control among individuals with Chronic Obstructive Pulmonary Disease (COPD) compared to healthy individuals. It utilizes advanced signal processing methods to analyze force signals recorded during submaximal isometric contractions of knee extensors. Participants perform contractions at varying intensities of their maximal muscle strength, allowing researchers to assess force variability and control. The study aims to provide insights into how COPD affects muscle function during daily activities.

Who should consider this trial

Good fit: Ideal candidates include French-speaking individuals aged 40 and over with stable COPD classified as GOLD II-IV and a FEV1 less than 80% of predicted values.

Not a fit: Patients with severe comorbidities or those unable to participate in physical assessments may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved rehabilitation strategies for COPD patients by enhancing our understanding of their muscle control capabilities.

How similar studies have performed: While there is growing research on motor impairments in COPD, this specific focus on force control using advanced methodologies is relatively novel.

Eligibility criteria

Inclusion Criteria:

COPD patients :

* GOLD II - III or IV
* FEV1 \<80% of predicted values
* Men and women aged 40 years and over
* French-speaking participant
* BMI \<30 kg / m²
* Stable condition (i.e. without exacerbation) for more than 15 days
* Able to express their consent in writing prior to any participation in the study
* Affiliates or beneficiaries of a social security
* Minimum score of 26 on the MMSE questionnaire of 3 months or less

Healthy volunteers :

* Men and women aged 40 years and over
* French-speaking participant
* BMI \<30 kg / m²
* No known chronic respiratory, cardiovascular, metabolic, renal or neuromuscular pathologies
* Able to express their consent in writing prior to any participation in the study
* Affiliates or beneficiaries of a social security
* Minimum score of 26 on the MMSE questionnaire of 3 months or less

For all participants :

-Subject who has not objected to the reuse of data collected

Exclusion Criteria:

COPD patients :

* Alcoholism, i.e. \> 21 glasses a week for men and \>14 glasses a week for women
* Psychiatric pathologies or antecedent of behavioral disorders
* Patients treated with oral or systemic corticosteroids (\> 0.5 mg / kg / day for \> 7 days)
* Contraindication to the application of a magnetic field (i.e. right hip arthroplasty, pelvic / abdominal surgeries)
* Severe vision or hearing problems not corrected
* Patient oxygen dependent
* Patients in exclusion period from another research protocol
* Pregnant women (known pregnancy) or lactating women
* Patient deprived of liberty by a judicial or administrative decision
* Patient subject to a legal protection measure or unable to express their consent
* Patient who is not sufficiently fluent in reading and understanding the French language to be able to consent to participate in the study
* Patient unable to follow study procedures and to respect visits throughout the study period
* Person with a medical history that, in the opinion of the investigator, could interfere with the results of the study
* Any condition that, in the opinion of the investigator, could increase and compromise the safety of the person in the event that he / she participates in the study
* Any other reason that, in the opinion of the investigator, could interfere with the evaluation of the aims of the study

Healthy volunteers:

* Alcoholism, i.e. \> 21 glasses a week for men and \>14 glasses a week for women
* Psychiatric pathologies or antecedent of behavioral disorders
* Patients treated with oral or systemic corticosteroids (\> 0.5 mg / kg / day for \> 7 days)
* Contraindication to the application of a magnetic field (i.e. right hip arthroplasty, pelvic / abdominal surgeries)
* Severe vision or hearing problems not corrected
* Subjects in exclusion period from another research protocol
* Pregnant women (known pregnancy) or lactating women
* Regular physical activity with a frequency greater than 3 sessions per week
* Participant deprived of liberty by a judicial or administrative decision
* Participant subject to a legal protection measure or unable to express their consent
* Participant who is not sufficiently fluent in reading and understanding the French language to be able to consent to participate in the study
* Participant unable to follow study procedures and to respect visits throughout the study period
* Person with a medical history that, in the opinion of the investigator, could interfere with the results of the study
* Any condition that, in the opinion of the investigator, could increase and compromise the safety of the person in the event that he / she participates in the study
* Any other reason that, in the opinion of the investigator, could interfere with the evaluation of the aims of the study

Where this trial is running

Toulon, VAR

• Université de Toulon, laboratoires Laboratoire J-AP2S — Toulon, VAR, France (RECRUITING)

Study contacts

• Study coordinator: Asmaa JOBIC

Conditions: Chronic Obstructive Pulmonary Disease, COPD, Muscle, Force control, Non-linear, Variability, Isometric contractions