Understanding muscle connective tissue in limb development and radial dysplasia
Official title: Muscle Connective Tissue in Limb Development and Disease
Run by King's College London · NCT02611089 · Data updated 2026-11-12
This study looks at how problems in muscle tissue might cause issues in limb development for people with radial dysplasia to help improve treatment options.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | King's College London Academic / other |
| Locations | 5 sites (Oxford, Oxfordshire and 4 other locations) |
| Status | Recruiting |
| Started | February 20, 2016 |
| Main results expected | February 1, 2026 |
| Study ends | August 2036 |
| Registry record updated | August 27, 2025 |
| Trial ID | NCT02611089 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include patients with a clinical diagnosis of radial dysplasia who require reconstructive surgery.
✕Probably not a fit
Patients with radial dysplasia who do not require reconstructive surgery or those with other diagnoses will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to investigate how disruptions in muscle connective tissue contribute to soft tissue defects in patients with radial dysplasia, a limb anomaly. Researchers will compare tissue samples from patients undergoing corrective hand surgery with those from patients having other hand surgeries to identify differences in tissue architecture and cellular composition. The goal is to enhance understanding of normal limb development and improve treatment strategies for radial dysplasia. By examining post-natal muscle connective tissue derivatives, the study seeks to address an ongoing challenge in managing this condition.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for children with radial dysplasia.
How similar studies have gone: While this approach is based on previous findings in experimental models, it is novel in its application to human patients.
Who can join: the full rules
Show full inclusion / exclusion criteria
Cases Inclusion Criteria: * Patients with a clinical diagnosis of radial dysplasia, requiring reconstructive surgery * Either sex * Informed (parental) consent to participate Exclusion Criteria: * Patients with a clinical diagnosis of radial dysplasia, but not requiring reconstructive surgery * Patients with a diagnosis other than radial dysplasia * Patients with extensive previous scarring to their forearm and hand. * Patients with a significant pathological skin or soft tissue lesion at the donor site. Controls Inclusion Criteria: * Patients with an injury requiring reconstructive surgery * Either sex * Informed (parental) consent to participate Exclusion Criteria: * Patients with extensive previous scarring to their forearm and hand. * Patients with a significant pathological skin or soft tissue lesion at the donor site.
Where it's running
-
Oxford University Hospitals
Oxford, Oxfordshire, United Kingdom Recruiting -
Royal Free Hospital
London, United Kingdom Recruiting -
Guy's and St Thomas' Hospital
London, United Kingdom Recruiting -
Chelsea and Westminster Hospital NHS Foundation Trust
London, United Kingdom Recruiting -
Great Ormond Street Hospital for Children NHS Foundation Trust
London, United Kingdom Recruiting
Study contacts
- Principal investigator: Branavan Sivakumar, FRCS(Plast) — Great Ormond Street Hospital for Children NHS Foundation Trust
- Study coordinator: Malcolm Logan, BSc PhD
- Email: malcolm.logan@kcl.ac.uk
- Phone: 02078486886
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.