Understanding motor adaptation in Parkinson's disease patients
Movement Error-processes and Sensorimotor Adaptation in Parkinsonian Patient
This study is trying to see how well people with Parkinson's disease can adapt their movements when things change around them and what brain activity is involved in that process.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Assistance Publique Hopitaux De Marseille Academic / other |
| Locations | 1 site (Marseille) |
| Trial ID | NCT03371407 on ClinicalTrials.gov |
What this trial studies
This project aims to explore the relationship between behavioral deficits and electrophysiological anomalies in patients with Parkinson's disease (PD) during tasks that require motor adaptation to visual or mechanical changes. It focuses on understanding how the basal ganglia contribute to movement execution adaptation, moving beyond traditional studies that primarily examined implicit learning processes. By assessing both behavioral performance and EEG activity, the study seeks to identify the mechanisms involved in motor adaptation in PD patients at various stages of the disease.
Who should consider this trial
Good fit: Ideal candidates include right-handed adults over 18 years with idiopathic Parkinson's disease for more than 5 years and specific neurological criteria.
Not a fit: Patients who are pregnant, unable to provide informed consent, or have significant cognitive impairments may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance our understanding of motor adaptation in Parkinson's disease, potentially leading to improved therapeutic strategies.
How similar studies have performed: While the study explores novel aspects of motor adaptation in PD, similar studies have indicated the importance of the basal ganglia in movement control, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient aged over 18 years * Right-handed patients , following the Modified Edinburgh Handedness Inventory * Patient with Parkinson's disease according to Gibb criteria * Idiopathic Parkinson's Disease with a history of more than 5 years * Stimulation electrodes implanted in the 2 subthalamic nuclei in the Functional and Stereotactic Neurosurgery Department of La Timone Hospital (Pr REGIS). * Dopa-sensitivity greater than 50% * Absence of signs of cognitive impairment * Patient who agreed to participate in the study and signed informed consent * Patient affiliated with a health insurance Exclusion Criteria: * Person not likely to participate in the entire study * Pregnant or likely to be pregnant during the year * Patients unable to give their informed consent (detainees, adults under guardianship) * Person unable to understand the nature and purpose of the study, or presneting with understanding difficulties which could compromise the proper conduct of the study * Person refusing to sign the Informed Consent Form * A person who is able to give his or her consent but unable to read / write French language * patient who can not participate in an MRI study according to the criteria listed in the attached form.
Where this trial is running
Marseille
- Service de Neurologie, Hôpital de la Timone, Assistance Publique Hôpitaux de Marseille — Marseille, France (Recruiting)
Study contacts
- Study coordinator: Alexandre EUSEBIO, MD, PHD
- Email: alexandre.eusebio@ap-hm.fr
- Phone: +33491384333
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.