Understanding motor adaptation in Parkinson's disease patients
Official title: Movement Error-processes and Sensorimotor Adaptation in Parkinsonian Patient
Run by Assistance Publique Hopitaux De Marseille · NCT03371407 · Data updated 2026-11-12
This study is trying to see how well people with Parkinson's disease can adapt their movements when things change around them and what brain activity is involved in that process.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Assistance Publique Hopitaux De Marseille Academic / other |
| Locations | 1 site (Marseille) |
| Status | Recruiting |
| Started | July 4, 2019 |
| Main results expected | October 2027 |
| Study ends | October 2027 |
| Registry record updated | January 5, 2024 |
| Trial ID | NCT03371407 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include right-handed adults over 18 years with idiopathic Parkinson's disease for more than 5 years and specific neurological criteria.
✕Probably not a fit
Patients who are pregnant, unable to provide informed consent, or have significant cognitive impairments may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This project aims to explore the relationship between behavioral deficits and electrophysiological anomalies in patients with Parkinson's disease (PD) during tasks that require motor adaptation to visual or mechanical changes. It focuses on understanding how the basal ganglia contribute to movement execution adaptation, moving beyond traditional studies that primarily examined implicit learning processes. By assessing both behavioral performance and EEG activity, the study seeks to identify the mechanisms involved in motor adaptation in PD patients at various stages of the disease.
Why it matters
Potential benefit: If successful, this study could enhance our understanding of motor adaptation in Parkinson's disease, potentially leading to improved therapeutic strategies.
How similar studies have gone: While the study explores novel aspects of motor adaptation in PD, similar studies have indicated the importance of the basal ganglia in movement control, suggesting potential for success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient aged over 18 years * Right-handed patients , following the Modified Edinburgh Handedness Inventory * Patient with Parkinson's disease according to Gibb criteria * Idiopathic Parkinson's Disease with a history of more than 5 years * Stimulation electrodes implanted in the 2 subthalamic nuclei in the Functional and Stereotactic Neurosurgery Department of La Timone Hospital (Pr REGIS). * Dopa-sensitivity greater than 50% * Absence of signs of cognitive impairment * Patient who agreed to participate in the study and signed informed consent * Patient affiliated with a health insurance Exclusion Criteria: * Person not likely to participate in the entire study * Pregnant or likely to be pregnant during the year * Patients unable to give their informed consent (detainees, adults under guardianship) * Person unable to understand the nature and purpose of the study, or presneting with understanding difficulties which could compromise the proper conduct of the study * Person refusing to sign the Informed Consent Form * A person who is able to give his or her consent but unable to read / write French language * patient who can not participate in an MRI study according to the criteria listed in the attached form.
Where it's running
-
Service de Neurologie, Hôpital de la Timone, Assistance Publique Hôpitaux de Marseille
Marseille, France Recruiting
Study contacts
- Study coordinator: Alexandre EUSEBIO, MD, PHD
- Email: alexandre.eusebio@ap-hm.fr
- Phone: +33491384333
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.