Understanding micro-expressions in patients with prolonged disorders of consciousness

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate micro-expressions in patients with prolonged disorders of consciousness by exposing them to various emotional stimuli. It seeks to classify their levels of consciousness more accurately and assist in clinical diagnosis by complementing existing scales like the CRS-R scale. The study will involve approximately 200 participants, including both patients and healthy controls, and will utilize assessments of responsiveness, EEG, and MRI data to explore residual brain function. Follow-up evaluations will be conducted over a period of six months to monitor changes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients with consciousness disorders for more than 28 days following severe brain injury, assessed by the CRS-R scale to meet the criteria for VS or MCS;
2. Aged between 18 and 80 years;
3. Stable vital signs;
4. Voluntary participation of family members with signed informed consent;
5. Good cooperation, minimal facial and spontaneous activities, no use of antiepileptic or sedative drugs.

Exclusion Criteria:

1. Locked-in syndrome;
2. Contraindications for EEG examination;
3. Contraindications for MRI scanning, such as the presence of internal metallic implants;
4. Diseases and factors that may affect brain function assessment, such as metabolic disorders, poisoning, shock, etc.

Where it's running

• First Affiliated Hospital,Zhejiang University
  Hangzhou, Zhejiang, China Recruiting

Study contacts

• Principal investigator: Benyan Luo, Doctor — Zhejiang University
• Study coordinator: Fangping He, Master
• Email: hefangping@zju.edu.cn
• Phone: 86-13819114225

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Targeted thalamic ultrasound to help recovery after severe brain injury

  This will try focused ultrasound to the thalamus to see if it helps people with a prolonged disorder of consciousness after traumatic brain injury.

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• Using Vagus Nerve Stimulation and Robotic Mobilization for Patients with Prolonged Disorders of Consciousness

  This study is testing if combining a special nerve stimulation treatment with robotic help to move can improve the recovery of patients who have been in a prolonged state of unconsciousness.

  Recruiting Icahn School of Medicine at Mount Sinai · New York, New York · NCT06930716

• Measuring brain activity to assess consciousness recovery in ICU patients

  This study is testing a new method using brain scans to see if it can help doctors understand if ICU patients with severe brain injuries are aware and how likely they are to recover.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts and 1 other locations · NCT06568536

• Investigating brain activity and consciousness in patients with severe brain injuries

  This study is testing a new way to monitor brain activity in patients with severe brain injuries to see if it can help doctors understand their level of consciousness and improve their treatment.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven, Vlaams-Brabant · NCT06426615

• Observing micro-movements in patients with prolonged disorders of consciousness

  This study is trying to see if tiny movements in patients with prolonged disorders of consciousness can help us understand their level of awareness and improve their care.

  Recruiting First Affiliated Hospital of Zhejiang University · Hanzhou, Zhejiang · NCT06406413

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.