Understanding lymph node metastasis patterns in left-sided colorectal cancer
Real World Registry Study on the No.253 Lymph Node Metastasis Patterns in Left-Sided Colon and Rectal Cancer
This study is trying to learn more about how cancer spreads to a specific lymph node in people with left-sided colorectal cancer to better understand their risks and outcomes.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 3000 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | Cancer Institute and Hospital, Chinese Academy of Medical Sciences Academic / other |
| Locations | 4 sites (Beijing, Beijing Municipality and 3 other locations) |
| Trial ID | NCT06135571 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the metastasis patterns of the No.253 lymph node in patients with left-sided colorectal cancer. It will analyze risk factors for metastasis and the prognosis for patients who have metastasis to this specific lymph node. The study includes patients aged 18-75 who have undergone laparoscopic surgery for descending colon, sigmoid colon, or rectal cancer, with confirmed adenocarcinoma and no distant metastasis. By providing definitive clinical evidence, this research seeks to enhance the understanding of lymphatic spread in colorectal cancer.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-75 who have undergone specific laparoscopic surgeries for left-sided colorectal cancer and have confirmed adenocarcinoma.
Not a fit: Patients with a history of malignant colorectal tumors or those undergoing emergency surgeries may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve surgical strategies and outcomes for patients with left-sided colorectal cancer.
How similar studies have performed: While there have been retrospective studies on lymph node metastasis, this study's registry-based approach is novel and aims to provide clearer insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age: 18-75 years; 2. Underwent laparoscopic left hemicolectomy, sigmoid colectomy, or rectal cancer radical surgery. 3. Postoperative pathology confirmed as adenocarcinoma. 4. No evidence of distant metastasis. Exclusion Criteria: 1. Previous history of malignant colorectal tumors. 2. Patients who have undergone multiple abdominal-pelvic surgeries. 3. Patients undergoing emergency surgery due to complications such as intestinal obstruction, intestinal perforation, or intestinal bleeding. 4. Surgery did not achieve R0 resection. 5. Patients with concurrent other malignant tumors or multiple primary colorectal cancers. 6. Patients unwilling to sign an informed consent or follow the study protocol for follow-up.
Where this trial is running
Beijing, Beijing Municipality and 3 other locations
- Peking Union Medical College Hospital — Beijing, Beijing Municipality, China (Recruiting)
- China-Japan Friendship Hospital — Beijing, Beijing Municipality, China (Recruiting)
- Beijing Cancer Hospital — Beijing, Beijing Municipality, China (Recruiting)
- Chinese PLA General Hospital — Beijing, Beijng, China (Recruiting)
Study contacts
- Study coordinator: Qian Liu, Dr.
- Email: fcwpumch@163.com
- Phone: 13601008906
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.