Understanding lung injury from ozone exposure
Official title: Activated Macrophages and Ozone Toxicity II
Run by Rutgers, The State University of New Jersey · NCT05794087 · Data updated 2026-11-12
This study is testing how breathing in ozone affects lung injury by looking at immune cell activity in the mucus of people who will exercise after being exposed to both clean air and ozone.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 40 Years |
| Sex | All |
| Enrollment | 120 (estimated) |
| Sponsor | Rutgers, The State University of New Jersey Academic / other |
| Locations | 1 site (Piscataway, New Jersey) |
| Status | Recruiting |
| Started | February 7, 2023 |
| Main results expected | June 1, 2027 |
| Study ends | June 1, 2027 |
| Registry record updated | December 17, 2025 |
| Trial ID | NCT05794087 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are healthy individuals who are vaccinated against COVID-19 and can produce sputum samples.
✕Probably not a fit
Patients with cardiovascular or respiratory diseases, recent respiratory symptoms, or other specified health conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to investigate how ozone exposure affects lung injury by analyzing macrophage activity in sputum samples. Participants will undergo two exposure sessions, one to filtered air and another to 0.2 ppm ozone, with at least two weeks between sessions. Each session will involve physical activity on an exercise bicycle, and follow-up visits will include sputum, blood, and exhaled breath sample collections for analysis. The study is conducted at the Rutgers EOHSI clinical center in Piscataway, NJ.
Why it matters
Potential benefit: If successful, this study could lead to a better understanding of lung injury mechanisms, potentially informing treatment strategies for those affected by air pollution.
How similar studies have gone: While studies on air pollution and lung injury exist, this specific approach focusing on macrophage activity in response to ozone exposure is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Exclusion Criteria: * Cardiovascular disease * Respiratory disease * Recent (within 4 weeks) respiratory or COVID-19 symptoms * Diabetes * Pregnancy * HIV Infection * History of smoking within the past 5 years. * Orthopedic or rheumatologic conditions which would interfere with cycle use * Inability to produce a sputum plug at screening * Daily use of antioxidant supplements, excluding those in a multivitamin. These supplements include Vitamin C or E, selenium, beta-carotene, lycopene, lutein, zeaxanthin and ginkgo biloba. Supplements taken less frequently but at least once a week will be reviewed by the principal investigator for eligibility determination.
Where it's running
-
Rutgers - EOHSI
Piscataway, New Jersey, United States Recruiting
Study contacts
- Principal investigator: Howard M Kipen, MD — Rutgers School of Public Health
- Study coordinator: Kathleen Black, PhD
- Email: kgblack@eohsi.rutgers.edu
- Phone: 8484456049
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.