Understanding long-term effects of pediatric intensive care on patients and their siblings

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to characterize the long-term physical and cognitive health outcomes of children who survive a stay in the pediatric intensive care unit (PICU). It includes two cohorts: one focusing on PICU survivors and the other on their healthy siblings, assessing their quality of life and support needs after the critically ill child's discharge. The study will investigate risk factors associated with poor health outcomes in PICU survivors and explore the broader impact of critical illness on family dynamics. By emphasizing patient-reported outcomes, the research seeks to identify challenges and solutions for improving survivorship experiences.

Why it matters

Who can join: the full rules

Inclusion Criteria:

\[HOPE Cohort\]

1. Between 28 days - 16 years of age at PICU admission
2. Have an expected PICU stay \> 48 hours\*

\[SHACK-S Cohort\]

1. Healthy children (aged 4 -16 years old) with critically ill sibling between 28 days - 16 years of age at PICU admission
2. Has a critically ill sibling who has an expected PICU stay \> 48 hours
3. Lives in the same household as the critically ill sibling and parents prior to admission

Exclusion Criteria:

\[HOPE Cohort\]

1. Do-Not-Resuscitate status
2. Lack of informed consent
3. Prior enrolment in this study

\[SHACK-S Cohort\]

1. Children of critically ill sibling with Do-Not-Resuscitate status
2. Children with condition listed on paediatric Complex Chronic Conditions (CCC) system Version 3.0 or with neurocognitive/neurodevelopmental delays or disorders
3. Previous admission to PICU
4. Lack of informed consent
5. Prior enrolment in this study

   * Note: For participating study sites without a dedicated PICU (e.g., sites where patients are managed in a combined ward under High Dependency (HD) or ICU status), PICU stay will be defined as the duration during which the patient is assigned an ICU status. The determination of ICU status will be made at the discretion of the respective site's study team and Site-PI.

Where it's running

• National University Singapore
  Singapore, Singapore, Singapore Recruiting
• KK Women's and Children's Hospital
  Singapore, Singapore, Singapore Recruiting

Study contacts

• Principal investigator: A/Prof Lee Jan Hau, MBBS, MRCPCH, MCI — KK Women's and Children's Hospital
• Study coordinator: Eric Jia Yong Ong, BSc (Hons)
• Email: eric.ong.j.y@kkh.com.sg
• Phone: +65 62255554

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Hypnosis to improve well-being after an ICU stay

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.