Understanding infections in aortic and large arterial vessels
Official title: French Registry Studying the Characteristics and Prognosis of Aortic and Large Arterial Vessel Infections
Run by Central Hospital, Nancy, France · NCT05660733 · Data updated 2026-11-12
This study looks at rare infections in large blood vessels to better understand them and improve how they are treated.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | Central Hospital, Nancy, France Academic / other |
| Locations | 1 site (Vandœuvre-lès-Nancy, Lorraine) |
| Status | Recruiting |
| Started | June 30, 2023 |
| Main results expected | January 1, 2027 |
| Study ends | January 1, 2027 |
| Registry record updated | August 8, 2025 |
| Trial ID | NCT05660733 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 and older who have been diagnosed with an aortic or large arterial vessel infection.
✕Probably not a fit
Patients who are pregnant, breastfeeding, or have legal restrictions preventing participation will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study focuses on aortic and large arterial vessel infections, which are rare but serious conditions. It aims to gather data on patients diagnosed with these infections to better understand their complexity and polymorphism. The study will utilize clinical presentations, biological markers, and imaging evidence to confirm diagnoses. By collecting this information, the research seeks to improve management guidelines based on expert opinions and existing literature, which currently lacks robust interventional studies.
Why it matters
Potential benefit: If successful, this study could lead to improved management strategies for patients suffering from aortic and large arterial vessel infections.
How similar studies have gone: While there is limited interventional research in this area, the study aims to build on existing expert opinions and case series, indicating a need for further investigation rather than a completely novel approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years * Aortic or large arterial vessel infection. The diagnosis is made on a number of criteria in favour of the diagnosis (at least 2 of the following 3 criteria): * Compatible clinical presentation: local or general inflammatory signs suggestive of a deep infection (fever, chills, scar discharge, fistula, febrile abdominal pain and low back pain, ...) or per-operative finding of an infection in contact with native or prosthetic vascular tissue * And/or biological (inflammatory syndrome) and/or imaging evidence (infectious sign on native, bioprosthetic or prosthetic vascular tissue on CT and/or PET scan) in favour of the diagnosis * And/or microbiological evidence (positive serologies, blood cultures or deep samples in favour of infection) Exclusion Criteria: * Patient who objected to participation in this protocol and data collection * Pregnant woman, parturient or breastfeeding mother * Person deprived of liberty by a judicial or administrative decision, * Person subject to psychiatric care by virtue of articles L.3212-1 and L.3213-1 of the French public health code * Person subject to a legal protection measure * Person unable to give consent
Where it's running
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Université de Lorraine, CHRU Nancy and APEMAC
Vandœuvre-lès-Nancy, Lorraine, France Recruiting
Study contacts
- Principal investigator: Lefèvre Benjamin, M.D. — Université de Lorraine & CHRU de Nancy
- Study coordinator: Lefèvre Benjamin, M.D.
- Email: b.lefevre@chru-nancy.fr
- Phone: +33383157654
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.