Understanding immune function in type 1 diabetes
Immune Function and the Progression to Type 1 Diabetes:
University of Florida · NCT05899439
This study looks at how certain genes linked to type 1 diabetes affect the immune system and its role in causing the disease.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 2800 (estimated) |
| Ages | 0 Years to 100 Years |
| Sex | All |
| Sponsor | University of Florida (other) |
| Locations | 3 sites (Gainesville, Florida and 2 other locations) |
| Trial ID | NCT05899439 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore how specific genes associated with type 1 diabetes influence immune system abnormalities that lead to the disease. It will investigate the inflammatory signals that attract immune cells to the pancreas, examine how these cells move through blood vessels to their target sites, and characterize the immune signatures related to type 1 diabetes in both blood and immune tissues. The research will focus on the impact of genetic risk factors on immune cell behavior and function, contributing to a better understanding of the autoimmune processes involved in type 1 diabetes.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals who are able to have blood drawn and are at risk for or have type 1 diabetes.
Not a fit: Patients who are unable to provide blood samples may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding of type 1 diabetes mechanisms, potentially guiding new therapeutic strategies.
How similar studies have performed: Other studies have shown success in understanding immune mechanisms in type 1 diabetes, making this approach promising.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: able to have blood drawn - Exclusion Criteria: none \-
Where this trial is running
Gainesville, Florida and 2 other locations
- Kieran McGrail — Gainesville, Florida, United States (RECRUITING)
- The Ohio State University — Columbus, Ohio, United States (RECRUITING)
- Baylor College of Medicine, Center for Research Advancement - Texas Children's Hospital — Houston, Texas, United States (RECRUITING)
Study contacts
- Study coordinator: Jennifer L Hosford, MPH
- Email: jennifer.hosford@peds.ufl.edu
- Phone: 352-294-5759
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Type 1 Diabetes