Understanding immune function in type 1 diabetes
Official title: Immune Function and the Progression to Type 1 Diabetes:
Run by University of Florida · NCT05899439 · Data updated 2026-11-12
This study looks at how certain genes linked to type 1 diabetes affect the immune system and its role in causing the disease.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 0 Years to 100 Years |
| Sex | All |
| Enrollment | 2800 (estimated) |
| Sponsor | University of Florida Academic / other |
| Locations | 3 sites (Gainesville, Florida and 2 other locations) |
| Status | Recruiting |
| Started | January 1, 2005 |
| Main results expected | January 1, 2085 |
| Study ends | January 1, 2085 |
| Registry record updated | April 9, 2026 |
| Trial ID | NCT05899439 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals who are able to have blood drawn and are at risk for or have type 1 diabetes.
✕Probably not a fit
Patients who are unable to provide blood samples may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to explore how specific genes associated with type 1 diabetes influence immune system abnormalities that lead to the disease. It will investigate the inflammatory signals that attract immune cells to the pancreas, examine how these cells move through blood vessels to their target sites, and characterize the immune signatures related to type 1 diabetes in both blood and immune tissues. The research will focus on the impact of genetic risk factors on immune cell behavior and function, contributing to a better understanding of the autoimmune processes involved in type 1 diabetes.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding of type 1 diabetes mechanisms, potentially guiding new therapeutic strategies.
How similar studies have gone: Other studies have shown success in understanding immune mechanisms in type 1 diabetes, making this approach promising.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: able to have blood drawn - Exclusion Criteria: none \-
Where it's running
-
Kieran McGrail
Gainesville, Florida, United States Recruiting -
The Ohio State University
Columbus, Ohio, United States Recruiting -
Baylor College of Medicine, Center for Research Advancement - Texas Children's Hospital
Houston, Texas, United States Recruiting
Study contacts
- Study coordinator: Jennifer L Hosford, MPH
- Email: jennifer.hosford@peds.ufl.edu
- Phone: 352-294-5759
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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This study tests whether weekly semaglutide changes body composition in adults with type 1 diabetes who are overweight or obese, compared with a placebo over 24 weeks.
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Next Generation Extended Wear Sensors in Type 1 and Type 2 Diabetes
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This study tests whether teaching mealtime insulin dosing using CGM data helps adults with Type 1 diabetes who don’t usually count carbs.
-
Safety and effectiveness of GLP-1 receptor agonists and SGLT inhibitors added to insulin in adults with type 1 diabetes
This registry will see if adding GLP-1RA or SGLTi therapies to insulin helps adults with type 1 diabetes over one year.
-
Think-Find-Solve activities for insulin self-management in children with type 1 diabetes
A behavior-change activity book is tested with children aged 8–12 with type 1 diabetes and their parents to see if it improves daily insulin self-management.
-
Near-sensor insulin delivery with CGM in people with type 1 diabetes
A small early-feasibility study tests a dual-port insulin patch pump that includes a CGM sensor to see if delivering insulin near the sensor affects glucose readings and whether an automated control algorithm can manage glucose.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.