Understanding how trastuzumab deruxtecan works in HER2 positive breast cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study utilizes a spatial transcriptomic approach to investigate the mechanisms of resistance to trastuzumab deruxtecan in patients with HER2 positive breast cancer. By analyzing formalin-fixed paraffin-embedded (FFPE) samples from patients who have undergone treatment, the study aims to uncover the biological factors that contribute to treatment resistance. The findings could provide insights into improving therapeutic strategies for this patient population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* HER2 positive breast cancer
* Stage IV disease
* Treated with T-Dxd
* Available FFPE samples

Exclusion Criteria:

* TNBC breast cancer
* Hormone receptor positive breast cancer
* Non-available FFPE samples
* Treated except T-Dxd

Where it's running

• Ji-Yeon Kim
  Seoul, South Korea Recruiting

Study contacts

• Study coordinator: Ji-Yeon Kim
• Email: jyeon25@skku.edu
• Phone: 82-2-3410-3459

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.