Understanding how to improve vision after central vision loss
Characterization of Multiple Factors in Training and Plasticity in Central Vision Loss: Healthy Vision
This study is testing different training methods to see if they can help people with central vision loss, like those with macular degeneration, improve their vision and daily activities.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 120 (estimated) |
| Ages | 18 Years to 30 Years |
| Sex | All |
| Sponsor | University of Alabama at Birmingham Academic / other |
| Locations | 2 sites (Birmingham, Alabama and 1 other locations) |
| Trial ID | NCT05439759 on ClinicalTrials.gov |
What this trial studies
This study investigates the factors influencing perceptual learning and plasticity in individuals with central vision loss, particularly focusing on macular degeneration. It aims to explore how different training methods can enhance visual sensitivity, spatial integration, and spatial attention in patients. By simulating central vision loss in normally seeing individuals, the research seeks to understand the relationship between visual experience changes and brain activity. The findings could lead to new therapies for improving daily visual tasks for those affected by low vision.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy adults aged 18-30 with corrected vision of 20/40 or better and no retinal pathology.
Not a fit: Patients with conditions such as retinal pathology, claustrophobia, or those who are pregnant will not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that significantly improve the quality of life for individuals with low vision.
How similar studies have performed: Other studies have shown promise in using perceptual learning approaches for vision improvement, indicating potential success for this novel investigation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged 18-30 * Corrected vision (20/40 or better) * No reported incidence of retinal pathology. Exclusion Criteria: * Pacemaker or any ferromagnetic metal implanted in their body * Metal of any type implanted in their head (limited dental work is acceptable) * Claustrophobia * Needing non-standard glasses (other than the simple MR-compatible glasses that can be supplied) for best-corrected distance vision * Being hearing-impaired * Weight over 300 pounds * Maximum body girth over 60 inches * Previous serious head injury * Presence of hallucinations or delusions * Excessive old, or colorful tattoos, especially near the head * Pregnancy * Braces/permanent retainer
Where this trial is running
Birmingham, Alabama and 1 other locations
- UAB — Birmingham, Alabama, United States (Recruiting)
- University of California, Riverside — Riverside, California, United States (Recruiting)
Study contacts
- Study coordinator: Rachel A Chua, MS
- Email: r2chel@uab.edu
- Phone: 205-410-4041
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.