Understanding how the immune environment affects chemotherapy resistance in colorectal cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the mechanisms of chemoresistance in colorectal cancer by developing tumoroids from fresh human primary colonic tumor tissue. It focuses on the role of the immune microenvironment in influencing tumor response to chemotherapy. By analyzing these tumoroids, researchers hope to identify new predictive markers for treatment response and develop personalized medicine strategies. The study targets patients with colorectal adenocarcinoma who are scheduled for surgical resection and have not yet received chemotherapy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male and female over 18 years old.
* Managed at the CHUGA for a colorectal adenocarcinoma
* With an indication for immediate surgical resection as part of the care.
* Patient naive from neo-adjuvant chemotherapy
* Patient did not object to the CRC-ORGA-2 study

Exclusion Criteria:

* Patients protected by law (pregnant or breastfeeding women, minors, patients under guardianship or trusteeship, persons deprived of their liberty or hospitalized under duress).
* Patients with positive HIV, HBV, HCV serology.

Where it's running

• University Hospital of Grenoble Alpes
  Grenoble, France Recruiting

Study contacts

• Principal investigator: Gael Roth, Md, Phd — university hospital of Grenoble alpes
• Study coordinator: Gael Roth, Md, Phd
• Email: GRoth@chu-grenoble.fr
• Phone: 04 76 76 51 68

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.