Clinical trial Recruiting at 1 site Interventional Ages 18 to 85

Understanding how the brain processes language using advanced neural data

Official title: Computational Neuroscience of Language Processing in the Human Brain

Run by Massachusetts General Hospital · NCT05222594 · Data updated 2026-11-12

This study tests how the brains of people with epilepsy process language by collecting detailed brain data while they perform language tasks.

Quick facts

Study typeInterventional
Ages18 Years to 85 Years
SexAll
Enrollment40 (estimated)
SponsorMassachusetts General Hospital
Academic / other
Locations1 site (Boston, Massachusetts)
StatusRecruiting
StartedApril 2, 2021
Main results expectedMarch 31, 2027
Study endsMarch 31, 2027
Registry record updatedMay 7, 2026
Trial IDNCT05222594 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 18 to 85 who require intracranial monitoring for epilepsy and can comply with study protocols.

Probably not a fit

Patients who do not have clinical indications for intracranial monitoring or who cannot understand or perform the required tasks may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the neural mechanisms underlying language processing by collecting high-quality neural data from patients with epilepsy who are undergoing intracranial monitoring. By utilizing behavioral tasks during these monitoring sessions, researchers aim to map the brain's response to various linguistic stimuli. The goal is to bridge the gap between neural data and computational models of language understanding, providing insights into how humans extract meaning from speech. This research could enhance our understanding of cognitive functions related to language.

Why it matters

Potential benefit: If successful, this study could lead to improved treatments for language-related disorders and enhance our understanding of cognitive neuroscience.

How similar studies have gone: While studies have explored aspects of language processing, this approach combining intracranial recordings with computational modeling is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* clinical indications to proceed with intracranial monitoring involving the left cerebral hemisphere, as determined by a multidisciplinary epilepsy surgery team
* the ability to comply with test directions and provide informed consent
* between ages 18 - 85

Exclusion Criteria:

* inability to understand or perform the task outlined in the protocol, or who are unwilling or unable to participate

Where it's running

  • Massachusetts General Hospital
    Boston, Massachusetts, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.