Understanding how the brain processes language

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the neurophysiological mechanisms underlying language comprehension in patients with epilepsy. Participants will read or listen to sentences presented one word at a time while their neural activity is recorded through implanted electrodes. The study consists of two phases: a recording-only phase where behavioral responses are measured, and a task-related stimulation phase where direct brain stimulation is applied. The aim is to correlate neural activity with language comprehension performance.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 and older
* Undergoing standard of care stereo Electro Encephalogram (sEEG) or Electro-Corticogram (ECoG) monitoring
* Able to competently perform control trials of the task

Exclusion Criteria:

* Age less than 18 years
* Unable to competently perform control trials of the task

Where it's running

• The University of Alabama at Birmingham Hospital
  Birmingham, Alabama, United States Recruiting

Study contacts

• Principal investigator: Matthew Nelson, PhD — The University of Alabama at Birmingham
• Study coordinator: Matthew Nelson, PhD
• Email: matthewnelson@uabmc.edu
• Phone: 2059346717

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• New tools to measure language, gestures, and everyday communication in people with aphasia

  This project will test new ways to measure language, gestures, and everyday communication skills in adults with aphasia after stroke.

  Recruiting IRCCS San Camillo, Venezia, Italy · Venice, VE · NCT07518576

• Exploring language disorders in patients with psychosis

  This study is trying to understand how language problems affect communication in people with psychosis, like schizophrenia, to see how these issues relate to their other symptoms.

  Recruiting Centre Psychothérapique de Nancy · Laxou, France · NCT06036316

• Effects of speech-language intervention on bilingual speakers with primary progressive aphasia

  This study tests if special speech therapy designed for bilingual people can help those with primary progressive aphasia communicate better in both of their languages.

  Recruiting at 2 sites University of Texas at Austin · Austin, Texas and 2 other locations · NCT05741853

• Improving language skills in people with aphasia

  This study is testing a new language treatment for people with aphasia to see if it helps them improve their speaking and understanding skills.

  Recruiting University of Arizona · Tucson, Arizona · NCT05443633

• Using leucovorin to improve social and language skills in young children with autism

  This study is testing if a liquid treatment called leucovorin can help improve social and language skills in young children with autism.

  Recruiting Phase 2 Southwest Autism Research & Resource Center · Phoenix, Arizona and 1 other locations · NCT04060030

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.