Clinical trial Recruiting at 1 site Observational Ages 18 and up

Understanding how the brain acquires language through intracranial recordings

Official title: Language Acquisition in the Brain and Algorithms: Towards Systematic Monitoring of the Evolution of Semantic Representations in Biological and Artificial Neural Networks

Run by Fondation Ophtalmologique Adolphe de Rothschild · NCT05217043 · Data updated 2026-11-12

This study is trying to see how children's brains learn language by recording their brain activity while they listen to stories and phrases.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment100 (estimated)
SponsorFondation Ophtalmologique Adolphe de Rothschild
Research network
Locations1 site (Paris, France)
StatusRecruiting
StartedJuly 15, 2022
Main results expectedFebruary 15, 2027
Study endsFebruary 15, 2027
Registry record updatedJanuary 5, 2026
Trial IDNCT05217043 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are children aged 2 to 20 years who are undergoing long-term intracranial brain recordings due to drug-resistant epilepsy.

Probably not a fit

Patients with complete deafness may not benefit from this study as the focus is on language acquisition through auditory stimuli.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the mechanisms of language acquisition in the brain by utilizing intracranial electroencephalography (iEEG) recordings in children with drug-resistant epilepsy. Participants will listen to pre-recorded phrases and stories while their brain activity is monitored, allowing researchers to analyze the evolution of semantic representations over time. The study focuses on understanding how the brain processes language and the development of semantic composition, which remains largely unexplored. By examining brain activity during these recordings, the study seeks to provide insights into the neural basis of language learning.

Why it matters

Potential benefit: If successful, this study could enhance our understanding of language acquisition, potentially leading to improved interventions for language-related disorders.

How similar studies have gone: While studies on language acquisition exist, this specific approach using intracranial recordings in children is relatively novel and has not been extensively tested.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Any patient benefiting from a long-term intracranial brain recording.
* Non-opposition to participating in the study (adult patients)
* Non-opposition of at least one of the holders of the exercise of parental authority (minor patients)

Exclusion Criteria:

* Patient with complete deafness

Where it's running

  • Fondation Ophtalmologique de Rothschild
    Paris, France, France
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.