Understanding how the brain acquires language through intracranial recordings
Official title: Language Acquisition in the Brain and Algorithms: Towards Systematic Monitoring of the Evolution of Semantic Representations in Biological and Artificial Neural Networks
Run by Fondation Ophtalmologique Adolphe de Rothschild · NCT05217043 · Data updated 2026-11-12
This study is trying to see how children's brains learn language by recording their brain activity while they listen to stories and phrases.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Fondation Ophtalmologique Adolphe de Rothschild Research network |
| Locations | 1 site (Paris, France) |
| Status | Recruiting |
| Started | July 15, 2022 |
| Main results expected | February 15, 2027 |
| Study ends | February 15, 2027 |
| Registry record updated | January 5, 2026 |
| Trial ID | NCT05217043 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are children aged 2 to 20 years who are undergoing long-term intracranial brain recordings due to drug-resistant epilepsy.
✕Probably not a fit
Patients with complete deafness may not benefit from this study as the focus is on language acquisition through auditory stimuli.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to explore the mechanisms of language acquisition in the brain by utilizing intracranial electroencephalography (iEEG) recordings in children with drug-resistant epilepsy. Participants will listen to pre-recorded phrases and stories while their brain activity is monitored, allowing researchers to analyze the evolution of semantic representations over time. The study focuses on understanding how the brain processes language and the development of semantic composition, which remains largely unexplored. By examining brain activity during these recordings, the study seeks to provide insights into the neural basis of language learning.
Why it matters
Potential benefit: If successful, this study could enhance our understanding of language acquisition, potentially leading to improved interventions for language-related disorders.
How similar studies have gone: While studies on language acquisition exist, this specific approach using intracranial recordings in children is relatively novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Any patient benefiting from a long-term intracranial brain recording. * Non-opposition to participating in the study (adult patients) * Non-opposition of at least one of the holders of the exercise of parental authority (minor patients) Exclusion Criteria: * Patient with complete deafness
Where it's running
-
Fondation Ophtalmologique de Rothschild
Paris, France, France Recruiting
Study contacts
- Study coordinator: Amélie YACHITZ
- Email: ayavchitz@for.paris
- Phone: (0)148036454
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.