Understanding how social factors affect transplant and cell therapy outcomes

Prospective Observational Cohort Study of Transplant and Cell Therapy Candidates and Recipients to Assess Social Determinants of Health

This study looks at how social and financial factors affect the success of transplant and cell therapy for patients at MD Anderson Cancer Center.

Quick facts

• Study type: Observational
• Enrollment: 2000 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: M.D. Anderson Cancer Center (other)
• Locations: 1 site (Houston, Texas)
• Trial ID: NCT06431347 on ClinicalTrials.gov

What this trial studies

This observational study aims to explore the impact of social determinants of health (SDOH) on the outcomes of patients undergoing transplant and cellular therapy at MD Anderson Cancer Center. It involves collecting data through a Social Determinants of Health Questionnaire and conducting semi-structured interviews with both patients and their caregivers. The study focuses on identifying social and financial challenges that may influence care delivery and treatment outcomes. By analyzing these factors, the research seeks to provide insights that could improve patient care and support.

Who should consider this trial

Good fit: Ideal candidates include adults aged 18 and older who are candidates or recipients of transplant and cell therapy at MD Anderson and report social or financial challenges.

Not a fit: Patients who do not face social or financial challenges or have not received financial clearance for transplant and cell therapy may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to enhanced understanding and support for patients facing social and financial barriers in transplant and cell therapy.

How similar studies have performed: While studies on social determinants of health are increasingly recognized, this specific approach focusing on transplant and cell therapy outcomes is relatively novel.

Eligibility criteria

Inclusion Criteria

1. ≥ 18 years of age.
2. Received financial clearance for TCT.

Qualitative study - patients

1. Patient ≥ 18 years of age who is currently cared for at MD Anderson as a TCT candidate/ recipient,
2. The patient reports social and/or financial challenges impacting care delivery.
3. The patient is willing to participate in a semi-structured interview.

Qualitative study - caregivers

1. Caregiver(s) of a patient ≥ 18 years of age who is currently cared for at MD Anderson as a TCT candidate/ recipient.
2. The patient reports social and/or financial challenges impacting care delivery.
3. The patient has referred the caregiver(s) to participate and provided us with permission to contact their caregiver(s).
4. The caregiver(s) is (are) willing to participate in a semi-structured interview.

Exclusion Criteria Patients - Quantitative study 1) Did not receive financial clearance for TCT

Patients - Qualitative study

1\) Not impacted by social or financial challenges.

Caregivers (qualitative study)

1. Did not care for a patient impacted by social or financial challenges
2. Were not referred to participate in the study by patient they cared for.

Where this trial is running

Houston, Texas

• MD Anderson Cancer Center — Houston, Texas, United States (RECRUITING)

Study contacts

• Principal investigator: Warren Fingrut, MD — M.D. Anderson Cancer Center
• Study coordinator: Warren Fingrut, MD

Conditions: Transplant and Cell Therapy, Social Determinants of Health