Understanding how pneumonia affects heart and lung health over time

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The HOMI-LUNG - HAP project investigates the long-term effects of hospital-acquired pneumonia on cardiovascular and respiratory diseases. It aims to quantify the burden of cardiovascular disease following pneumonia and evaluate patients' acceptance of health changes. The study will also identify different pneumonia endotypes linked to cardiovascular disease exacerbation. Various assessments, including blood samples, imaging, and exercise tests, will be conducted to gather comprehensive data on the participants' health.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Group A (patients with acute cardiac disease)

* Male or female
* Hospitalized for acute coronary syndrome for less than 7 days.
* Informed consent from the patient
* Person insured under a health insurance scheme

Group B (patients with chronic cardiovascular disease)

* Male or female,
* Undergoing coronary artery by-pass surgery
* Hospitalized in intensive care unit for \> 12 hours
* Informed consent from the patient
* Person insured under a health insurance scheme

Group C (patients at risk of CVRD without chronic cardiovascular disease)

* Male or female,
* Familial high levels of cholesterol or triglycerides
* With no personal history of CVRD, with a recent negative cardiac exercise test (last test inferior to 12 months)
* Follow-up for lipid abnormalities at high risk of CVRD events
* Informed consent from the patient
* Person insured under a health insurance scheme

Group D (patients with HAP)

* Male or female
* With one or more risk factors for CVD among:

Age ≥ 65 years old Smoking, Abnormal lipidic levels, High blood pressure, Obesity, Diabetes mellitus, Chronic kidney disease

* Cured from mechanically ventilated HAP during the current hospitalization
* Informed consent from the patient or relatives
* Person insured under a health insurance scheme

Exclusion Criteria:

* Groups A, B, C and D
* Age \<80 years old
* Immunosuppression pre-existing to the index hospitalisation, defined as lymphopenia; 500 elements/mm3, haematologic cancer, aplasia, chemotherapy/radiotherapy for cancer within 3 months prior to the inclusion, or anti-graft rejection drug.
* Pregnant women, breastfeeding women.
* Adults under guardianship or trusteeship.
* Low probability of survival at day 28.

  o Groups A, B, C
* Community-acquired pneumonia or Hospital-acquired pneumonia within the last year.

Where it's running

• Nantes University Hospital
  Nantes, France Recruiting
• Angers University Hospital
  Angers, France Not yet recruiting
• Rennes University Hospital
  Rennes, France Not yet recruiting
• Rouen University Hospital
  Rouen, France Not yet recruiting
• Toulouse University Hospital
  Toulouse, France Not yet recruiting

Study contacts

• Study coordinator: Antoine ROQUILLY
• Email: Antoine.roquilly@univ-nantes.fr
• Phone: +33253482840

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.