Understanding how patients respond to treatment for lichen planus
Clinical and Molecular Correlates of Response to First Line Treatment in Lichen Planus
This study is looking at how different factors affect how well patients with lichen planus respond to their first treatment with topical steroids.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 110 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Aberdeen Academic / other |
| Locations | 2 sites (Aberdeen, Aberdeen, Scotland and 1 other locations) |
| Trial ID | NCT05330572 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the clinical and molecular factors that influence the response to first-line treatment in patients with lichen planus, a painful inflammatory condition affecting the mouth and genital areas. Participants will be recruited from the Oral & Maxillofacial Unit and Aberdeen Dental School, with eligibility determined through a review of their medical records and biopsy confirmation of lichen planus. The study will focus on patients undergoing topical steroid therapy, assessing their responses to treatment while ensuring informed consent is obtained prior to data collection.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old with a confirmed diagnosis of lichen planus who are currently receiving topical steroid therapy.
Not a fit: Patients on systemic steroids, those with other systemic inflammatory conditions, or who are pregnant or lactating may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment strategies for patients suffering from lichen planus, enhancing their quality of life.
How similar studies have performed: While there have been studies on lichen planus, this specific observational approach focusing on clinical and molecular correlates is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged more than 18 years, with confirmed histopathological diagnosis of lichen planus and undergoing topical steroid therapy. * Participants who have the capacity to consent. * Participants who show a willingness to attend an initial appointment and a follow-up post-treatment appointment. Exclusion Criteria: * Patients on systemic steroids and other immunosuppressive agents for the treatment of lichen planus * Cases of graft versus host disease or those suffering from other systemic inflammatory conditions mimicking lichen planus (e.g. connective tissue disease). * Pregnant and lactating participants. * Inability to consent.
Where this trial is running
Aberdeen, Aberdeen, Scotland and 1 other locations
- University of Aberdeen — Aberdeen, Aberdeen, Scotland, United Kingdom (Enrolling_by_invitation)
- Aberdeen Dental School — Aberdeen, United Kingdom (Recruiting)
Study contacts
- Principal investigator: Dr Karolin Hijazi — University of Aberdeen
- Study coordinator: Dr Karolin Hijazi
- Email: k.hijazi@abdn.ac.uk
- Phone: 01224555153
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.