Understanding how older adults respond to combined exercise training
Official title: Multidimensional Predictive Modeling to Understand Mechanisms of Exercise Response Heterogeneity in Older Adults
Run by Florida Institute for Human and Machine Cognition · NCT06507189 · Data updated 2026-11-12
This study is testing how older adults respond to a mix of endurance and strength training exercises to see how it can improve their health and quality of life.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 60 Years and up |
| Sex | All |
| Enrollment | 250 (estimated) |
| Sponsor | Florida Institute for Human and Machine Cognition Academic / other |
| Locations | 2 sites (Pensacola, Florida and 1 other locations) |
| Status | Recruiting |
| Started | January 27, 2025 |
| Main results expected | July 31, 2028 |
| Study ends | August 31, 2029 |
| Registry record updated | August 10, 2026 |
| Trial ID | NCT06507189 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are healthy men and women aged 60 and above who have not engaged in structured exercise for the past year.
✕Probably not a fit
Patients with chronic diseases, neuromuscular disorders, or other conditions that limit exercise capacity may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to explore the variability in exercise responsiveness among older adults by implementing a combined endurance and resistance training program. It seeks to identify the biological mechanisms that contribute to differences in how individuals respond to exercise, which can affect their overall health and quality of life. The research involves an interdisciplinary team and aims to fill knowledge gaps regarding exercise response in aging populations. Participants will be closely monitored to assess their progress and outcomes from the training regimen.
Why it matters
Potential benefit: If successful, this study could enhance the effectiveness of exercise programs for older adults, leading to improved health outcomes and quality of life.
How similar studies have gone: Previous studies have shown varying success in understanding exercise response in older adults, but this approach of combining endurance and resistance training is innovative and less commonly tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Male or female aged 60 or above 2. Free of chronic disease 3. No structured exercise program (2 or more bouts/wk) within previous 12 months 4. Cognitively capable of providing informed consent Exclusion Criteria: 1. Neuromuscular or musculoskeletal disorder that would limit ability to perform the exercise and/or testing bouts 2. Cardiopulmonary disorders or reduced breathing capacity 3. Metabolic diseases including markers of liver disease (ALT \> 52 U/l) and type 2 diabetes (HbA1C = or \> 6.5, fasting blood glucose = or \> 126 mg/dl) 4. Any other disease or disorder that would influence exercise response (e.g., chronic kidney disease, dementia, current cancer diagnosis or within 2 yr remission, cerebrovascular disease) 5. Any current infectious disease 6. Life expectancy \< 1 year 7. Insulin sensitizing/blood glucose lowering agents such as metformin or metabolic weight loss agents (e.g. GLP-1 agonists) 8. High dose statin (dose equivalent of 40 mg/d or higher simvastatin) 9. Lidocaine allergy 10. Regular tobacco use and/or vaping 11. Excessive alcohol consumption (3 drinks/d or 7 drinks/wk for females; 4 drinks/d or 14 drinks/wk for males) 12. BMI 35.0 kg/m2 or higher 13. Unable to commit to \~6 months required to complete the study
Where it's running
-
Florida Institute for Human and Machine Cognition
Pensacola, Florida, United States Recruiting -
Oklahoma Medical Research Foundation
Oklahoma City, Oklahoma, United States Recruiting
Study contacts
- Principal investigator: Marcas Bamman — Florida Institute for Human and Machine Cognition
- Study coordinator: Craig Tuggle
- Email: ctuggle@ihmc.org
- Phone: 205-352-6036
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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100-Year Human Aging and Longevity Tracking Program
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-
Understanding frailty and pre-frailty in older adults
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-
Aquatic power training dosing strategies and creatine in older adults
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Intergenerational Interaction Program for Nursing Home Residents and Nursing Students
A 6-week program pairs nursing home residents with nursing students to see if weekly joint activities can increase joy and reduce loneliness for older adults and lessen ageism in students.
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Supplemental Mobility for older adults in skilled nursing facilities
This pilot tests whether adding a mobility aide to support walking and transfers alongside regular rehab helps older adults in SNFs after hospitalization see more daily activity and safer mobility.
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Smart Voice Platform to Support Quality of Life for Community-Living Older Adults
A smart voice platform is tested to see if it improves quality of life and healthy aging for older adults living in the community.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.