Understanding how obesity-related factors influence prostate cancer progression
Official title: Integrating Tissue-based Spatial Information to Elucidate How Obesity-induced Tumour Metabolites Drive Prostate Cancer Progression
Run by Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico · NCT06292897 · Data updated 2026-11-12
This study looks at how being overweight or obese affects prostate cancer by checking certain enzymes and immune cells in tumor samples from patients with different body weights.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | Men only |
| Enrollment | 25 (estimated) |
| Sponsor | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico Academic / other |
| Locations | 1 site (Milan) |
| Status | Recruiting |
| Started | March 20, 2023 |
| Main results expected | September 15, 2026 |
| Study ends | January 15, 2027 |
| Registry record updated | March 5, 2024 |
| Trial ID | NCT06292897 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients diagnosed with prostate cancer, particularly those with a BMI greater than 27.5.
✕Probably not a fit
Patients who are not affected by prostate cancer or have a BMI less than or equal to 27.5 may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study evaluates the expression of lactate dehydrogenase enzyme (LDHA) and MCT-1/-4 transporters in prostate cancer tissues from patients with varying body mass indices (BMI). It aims to characterize the immune cell presence in these tumors and assess how lactate accumulation relates to changes in the tumor immune environment and oncogenic pathways. By comparing severely overweight/obese patients to those with normal weight, the study seeks to uncover metabolic influences on cancer progression.
Why it matters
Potential benefit: If successful, this study could provide insights into how obesity impacts prostate cancer progression, potentially leading to targeted therapies.
How similar studies have gone: While the specific approach of this study may be novel, similar studies have explored the relationship between obesity and cancer progression, indicating potential for meaningful findings.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * affected by prostate cancer Exclusion Criteria: \-
Where it's running
-
IRCCS Cà Granda Ospedale Maggiore Policlinico Milano
Milan, Italy Recruiting
Study contacts
- Study coordinator: Giancarlo Albo, MD,
- Email: giancarlo.albo@policlinico.mi.it
- Phone: 00390255034501
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Fezolinetant to reduce hot flashes in men on androgen-deprivation therapy
This trial will test whether taking fezolinetant once daily for 4 weeks reduces how often and how severe hot flashes are in men with prostate cancer who are on androgen-deprivation therapy.
-
PSMA-targeted therapy with hormone suppression for low-volume metastatic prostate cancer
This phase II trial tests leuprolide acetate alone versus with 177Lu-PSMA-617 (with or without abiraterone acetate and prednisone) in men with hormone-sensitive, low-volume metastatic prostate cancer.
-
Lower-dose radiation to parts of the prostate for some men with prostate cancer
This study tests whether a smaller amount of radiation aimed at specific parts of the prostate can reduce side effects compared with giving the full prostate the same dose.
-
PSMA PET/CT plus MRI to find higher‑grade prostate cancer in men on active surveillance
This study tries adding rhPSMA-7.3 (flotufolastat F18) PET/CT to standard mpMRI to see if it finds higher-grade prostate cancer in men on active surveillance.
-
Using AI to help find prostate cancer on MRI
This study tests whether an AI software can help doctors find suspicious lesions on prostate MRI in men aged 55–80 who are having a pre-biopsy MRI and planned prostate biopsy.
-
Two-fraction radiotherapy for localized prostate cancer
This study is testing if giving radiotherapy in just two sessions instead of five can effectively treat localized prostate cancer while causing fewer side effects for patients.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.