Understanding how MK-8527 moves through the body in healthy adults
A Phase 1 Study to Evaluate the Absorption, Metabolism, and Excretion of [14C]MK-8527 in Healthy Adult Participants
This study is testing how a new compound called MK-8527 moves through the body in healthy adults to understand its safety and how it's processed.
Quick facts
| Phase | Phase 1 |
|---|---|
| Study type | Interventional |
| Enrollment | 8 (estimated) |
| Ages | 18 Years to 55 Years |
| Sex | Male |
| Sponsor | Merck Sharp & Dohme LLC Industry-sponsored |
| Locations | 1 site (Madison, Wisconsin) |
| Trial ID | NCT06826989 on ClinicalTrials.gov |
What this trial studies
This study aims to investigate the pharmacokinetics of the compound [14C]MK-8527 in healthy adult participants. Researchers will monitor how the compound is absorbed, metabolized, and excreted by the body over time. The study is designed to gather data on the safety and biological behavior of MK-8527 in a controlled environment. Participants will be closely observed to ensure their health and safety throughout the study.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy adults with a BMI between 18 and 32 kg/m².
Not a fit: Patients with a history of cancer or positive tests for hepatitis B, hepatitis C, or HIV may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide valuable insights into the metabolism of MK-8527, aiding in the development of future treatments.
How similar studies have performed: While this study focuses on a specific compound, similar pharmacokinetic studies have shown success in understanding drug behavior in healthy populations.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Is in good health * Has a body mass index (BMI) of 18 to 32 kg/m\^2 Exclusion Criteria: * Has a history of cancer * Has positive tests for hepatitis B surface antigen, hepatitis C antibodies or human immunodeficiency virus
Where this trial is running
Madison, Wisconsin
- Fortea CRU Madison ( 0001) — Madison, Wisconsin, United States (Recruiting)
Study contacts
- Study coordinator: Study Coordinator
- Email: Trialsites@msd.com
- Phone: 1-888-577-8839
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.