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Clinical trial No longer in our active list Observational Ages 18 and up Women only

Understanding how maternal stress affects blood sugar during pregnancy

Official title: Maternal Stress and Blood Sugar Metabolization During Pregnancy

Run by Sanford Health · NCT05798377 · Data updated 2026-05-14

This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.

This study looks at how stress and mental health during pregnancy affect blood sugar levels to see if it can help prevent gestational diabetes in women.

Quick facts

Study typeObservational
Ages18 Years and up
SexWomen only
Enrollment150 (estimated)
SponsorSanford Health
Academic / other
Locations1 site (Sioux Falls, South Dakota)
Trial IDNCT05798377 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are pregnant women aged 18 and older, who are less than 17 weeks into a healthy single baby pregnancy.

Probably not a fit

Patients with a history of diabetes, gestational diabetes, cardiac disease, endocrine disease, or those who have undergone in-vitro fertilization may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the relationship between maternal mental health, stress, and glucose metabolization during pregnancy, particularly focusing on gestational diabetes mellitus (GDM). By utilizing both retrospective and prospective approaches, the study aims to identify how these factors contribute to GDM and its associated racial disparities. The researchers hypothesize that stress moderates the impact of mental health on glucose metabolism, which may help in identifying at-risk women and improving preventative care options. The findings could lead to better management of GDM and reduced complications for mothers and their children.

Why it matters

Potential benefit: If successful, this study could enhance the identification and treatment of women at risk for gestational diabetes, ultimately improving maternal and child health outcomes.

How similar studies have gone: While the specific approach of this study may be novel, previous research has indicated that mental health and stress can significantly impact pregnancy outcomes, suggesting potential for success.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* At least 18 years old
* Less than 17 weeks
* Healthy single baby pregnancy

Exclusion Criteria:

* History of diabetes
* History of Gestational diabetes mellitus (GDM)
* History of cardiac disease
* History of endocrine disease
* Assistive reproductive technology (in-vitro fertilization)

Where it's running

  • Sanford Health
    Sioux Falls, South Dakota, United States     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.